Clinical trial Recruiting at 1 site Interventional Ages 18 to 50

Low-load resistance training with blood flow restriction for Achilles tendon pain

Official title: Effects of Low-load Resistance Training With Blood Flow Restriction in Patients With Achilles Tendinopathy

Run by University of Gran Rosario · NCT05241197 · Data updated 2026-11-12

This study is testing whether low-load resistance training with blood flow restriction can help people with chronic Achilles tendon pain feel better compared to regular high-load training.

Quick facts

Study typeInterventional
Ages18 Years to 50 Years
SexAll
Enrollment52 (estimated)
SponsorUniversity of Gran Rosario
Academic / other
Locations1 site (Rosario, Santa Fe Province)
StatusRecruiting
StartedApril 29, 2022
Main results expectedNovember 2025
Study endsAugust 2026
Registry record updatedDecember 6, 2024
Trial IDNCT05241197 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 18 to 50 with a clinical diagnosis of unilateral midportion Achilles tendinopathy lasting more than 3 months.

Probably not a fit

Patients with a history of ankle or foot surgery, systemic disorders, or those unable to perform the required exercises may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of low-load resistance training with blood flow restriction (BFR-LLT) compared to high-load training (HLT) in patients suffering from chronic midportion Achilles tendinopathy (MAT). A total of 52 participants aged 18 to 50 will be randomly assigned to either the BFR-LLT or HLT group, undergoing a 12-week rehabilitation program with assessments of pain, tendon thickness, and function at baseline, 6 weeks, and 12 weeks. The training will be conducted at the University of Gran Rosario, with evaluations performed by a blinded physiotherapist to ensure objectivity.

Why it matters

Potential benefit: If successful, this approach could provide a safer and more effective rehabilitation method for patients with Achilles tendinopathy.

How similar studies have gone: While low-load training with blood flow restriction has shown promise in other contexts, its application specifically for tendon pathology like Achilles tendinopathy is relatively novel and untested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Clinical diagnosis of unilateral MAT.
* Achilles pain \> 3 months.
* Age ranging between 18 to 50 years, both genders.
* Read and speak Spanish well enough to provide informed consent and follow study instructions.
* Can attend in-clinic treatments 2-3 x weekly for the next 12 weeks.

Exclusion Criteria:

* Any ankle or foot surgery.
* History of Achilles rupture.
* Heel pain in the last 3 months.
* Systemic disorders/diseases.
* History of deep venous thrombosis, hypertension or blood clotting disorder.
* Body mass index \> 30kg/m2.
* Self-report of pregnancy.
* Drug use (local steroid injection or systemic fluoroquinolones).
* Pain \< 2/10 of average pain on NPRS.
* VISA A score \> 90%.
* Unable to perform any of the exercises of the study.

Where it's running

  • University of Gran Rosario
    Rosario, Santa Fe Province, Argentina
    Recruiting

Study contacts

  • Principal investigator: Gonzalo Elias, PT — University of Gran Rosario
  • Study coordinator: Gonzalo Elias, PT
  • Email: gelias@ugr.edu.ar
  • Phone: 543416051190

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.