Low-dose aspirin for women with severe preeclampsia after delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether administering low-dose aspirin to women diagnosed with severe preeclampsia for three weeks postpartum can improve their endothelial function and reduce the severity of their condition. Participants will be randomly assigned to receive either low-dose aspirin or a placebo, with the primary outcome measured through flow-mediated dilation. The study also includes a comparison group of healthy postpartum women without preeclampsia. The goal is to gather data on the potential benefits of low-dose aspirin in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Singleton or Multiple gestation
* Maternal age \>= 18 years
* 20 0/7 weeks gestation or greater
* Severe Preeclampsia diagnosed prior to delivery

Exclusion Criteria:

* Aspirin use postpartum for other medical indication
* Lovenox, unfractionated heparin, or other anticoagulant use postpartum for an indication other than postoperative (in-house)
* Aspirin use within 7 days of planned initial FMD testing postpartum
* Hypersensitivity or allergy to Aspirin or other salicylates
* Hypersensitivity or allergy to nonsteroidal anti-inflammatory drugs (NSAIDs) - exception if taking LDA in pregnancy
* Nasal polyps
* Gastric or Duodenal ulcers, history of GI bleeding
* Severe hepatic dysfunction
* Bleeding disorders and diathesis
* Breastfeeding a newborn with low platelets (NAIT)

For sub-study patients, inclusion and exclusion criteria will be the same, with the exception of diagnosis of severe preeclampsia prior to delivery (exclusion criterion for healthy controls group).

Where it's running

• Columbia University Irving Medical Center
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Aleha Aziz, MD, MPH — Columbia University
• Study coordinator: Aleha Aziz, MD, MPH
• Email: aa4065@cumc.columbia.edu
• Phone: 646-678-0289

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postpartum Preeclampsia Care Using Point-of-Care Ultrasound and Diuretics

  The study tests whether using bedside ultrasound to guide diuretic therapy can improve outcomes for adults with preeclampsia after delivery.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT07167862

• Effects of high-salt intake on women after preeclampsia

  This study is testing how eating a lot of salt affects blood vessel health in women who had preeclampsia during pregnancy, to see if a medication can help improve their condition.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT06749418

• Using aspirin to help women recover from severe preeclampsia after childbirth

  This study tests if taking low-dose aspirin for a week after childbirth can help women recover faster from severe preeclampsia.

  Recruiting Phase 2 MemorialCare Health System · Long Beach, California · NCT05924971

• Using aspirin to reduce postpartum heart issues in women with preeclampsia

  This study is testing if taking aspirin after childbirth can help women with preeclampsia and high Activin A levels have better heart function.

  Recruiting Phase 4 University of Chicago · Chicago, Illinois · NCT04479072

• Nifedipine and Enalapril vs Nifedipine and Labetalol for Postpartum Hypertension

  This study tests whether adding enalapril to nifedipine better controls postpartum hypertension than adding labetalol.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07363343

• Postpartum Preeclampsia Early Detection and Treatment in Nepal: A Pilot Study

  This pilot study tests whether using sFlt-1/PlGF biomarker testing before delivery can predict postpartum preeclampsia and whether an early monitoring and treatment bundle helps high-risk, postpartum patients.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin and 1 other locations · NCT07185204

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.