Looking at how vascular grafts from older adults with coronary artery disease behave using single-cell gene analysis.
The Characteristics and Treatment Mechanism of Vascular Grafts in Elderly Patients With CAOD Through Single-cell Transcriptome Analysis
This project will collect leftover vessel grafts from people having coronary artery bypass surgery to see if single-cell and genomic analyses can reveal why grafts stiffen or remodel in older patients with coronary artery disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 19 Years to 100 Years |
| Sex | All |
| Sponsor | Yonsei University Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT07053254 on ClinicalTrials.gov |
What this trial studies
This observational effort collects discarded vascular graft tissue from patients undergoing coronary artery bypass grafting at a high-volume surgical center. Samples are split for molecular preservation (RNAlater) and for formalin-fixed histology so teams can run RNA sequencing, qPCR, western blotting, immunohistochemistry, and single-cell transcriptomics. The multi-omic approach aims to map cellular and molecular features linked to vascular remodeling and stiffness in elderly CAOD patients. All samples are obtained from excess tissue at the time of routine surgery, so no additional procedures or interventions are required.
Who should consider this trial
Good fit: Adults aged 19 years or older scheduled for coronary artery bypass grafting at the participating center who can give informed consent and are not undergoing concomitant valve correction or reoperative cardiac surgery.
Not a fit: Patients under 19, those needing valve surgery or reoperative bypass, and anyone who declines consent would not be included and therefore would not receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could identify biological targets to prevent graft failure or reduce vascular stiffness, improving long-term outcomes after bypass surgery.
How similar studies have performed: Single-cell and multi-omic analyses of cardiovascular tissues have previously identified mechanisms of vascular disease, but applying these techniques specifically to discarded CABG grafts from elderly CAOD patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 19 years or older, Patients scheduled to undergo coronary artery bypass grafting (CABG), Patients who voluntarily provide written informed consent for study participation, Patients who are able and willing to comply with study procedures during the study period Exclusion Criteria: * Pediatric or adolescent patients under 18 years of age, Patients requiring concomitant surgical correction for valvular heart disease, Patients undergoing reoperative (redo) cardiac surgery, Patients who decline to provide informed consent prior to surgery
Where this trial is running
Seoul
- Division of Cardiovascular Surgery, Severance Cardiovascular Hospital , Yonsei University College of Medicine — Seoul, South Korea (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.