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Long-term use of Tezspire for severe asthma in Japan

TEZSPIRE Subcutaneous Injection 210mg Specific Use-results Study (Long Term) in Patients With Bronchial Asthma.

Observational AstraZeneca · NCT05729711

This study is testing how safe and effective Tezspire is for people in Japan with severe asthma that isn't well controlled by other treatments.

Quick facts

Study typeObservational
Enrollment400 (estimated)
SexAll
SponsorAstraZeneca Industry-sponsored
Locations62 sites (Aichi and 61 other locations)
Trial IDNCT05729711 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate the long-term safety and effectiveness of Tezspire (tezepelumab) in patients with severe or intractable bronchial asthma that is not controlled by existing therapies. It will assess the development of related adverse events (AEs) and identify factors that may influence the treatment's safety and effectiveness. The findings will support regulatory re-examination under Japanese pharmaceutical law.

Who should consider this trial

Good fit: Ideal candidates are patients in Japan with severe or intractable bronchial asthma who are starting treatment with Tezspire for the first time.

Not a fit: Patients with mild or well-controlled asthma are unlikely to benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the long-term safety and effectiveness of Tezspire for patients with severe asthma.

How similar studies have performed: Other studies on Tezspire have shown promising results, indicating its potential effectiveness in managing severe asthma.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* The evaluable patients are those treated with Tezspire for the first time due to "Bronchial asthma (only the patients with severe or intractable bronchial asthma which could not be controlled with the existing therapy)

Exclusion Criteria:

None

Where this trial is running

Aichi and 61 other locations

+12 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Bronchial Asthma
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.