Long-term treatment continuation for patients who previously took adagrasib

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an open-label, phase 2, rollover trial enrolling patients from ongoing adagrasib studies who have NSCLC, colorectal cancer, or other advanced solid tumors. Participants may receive adagrasib alone or in combination with pembrolizumab, cetuximab, pemetrexed, or docetaxel, depending on prior benefit and protocol criteria. The study focuses on continuing treatment in patients who have demonstrated clinical benefit or meet parent-study continuation criteria. Exclusion criteria mirror the parent studies, including lack of ongoing benefit or prior toxicity leading to discontinuation. The trial is conducted at affiliated centers in Arizona and California under Mirati Therapeutics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit.
* Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF.

Exclusion Criteria:

* Participant is not eligible for study treatment per the parent study eligibility criteria.
* Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study.
* Participants not receiving clinical benefit from parent study drug as assessed by the investigator.

Other protocol defined inclusion/exclusion criteria applies.

Where it's running

• Southern California Permanente Medical Group
  Bellflower, California, United States Recruiting
• MemorialCare - Long Beach Medical Center
  Long Beach, California, United States Recruiting
• Florida Cancer Specialists - North
  St. Petersburg, Florida, United States Recruiting
• Cancer Center of Kansas
  Wichita, Kansas, United States Recruiting
• Mayo Clinic in Rochester, Minnesota
  Rochester, Minnesota, United States Recruiting
• Metro-Minnesota Community Oncology Research Consortium (MMCORC)
  Saint Paul, Minnesota, United States Recruiting

+51 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
• Email: Clinical.Trials@bms.com
• Phone: 855-907-3286

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.