Long-term study on adult disease and health variations
Official title: Longitudinal Collection of Observational Clinical and Lifestyle Data
Run by Weizmann Institute of Science · NCT05817734 · Data updated 2026-11-12
This study is trying to understand how different factors like genetics, health, and lifestyle affect disease risk and treatment responses in adults aged 40 to 70 over 25 years.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30000 (estimated) |
| Sponsor | Weizmann Institute of Science Academic / other |
| Locations | 1 site (Rehovot) |
| Status | Recruiting |
| Started | October 1, 2018 |
| Main results expected | December 31, 2045 |
| Study ends | December 31, 2045 |
| Registry record updated | July 16, 2024 |
| Trial ID | NCT05817734 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults aged 40-70 who are willing to participate in long-term follow-up assessments.
✕Probably not a fit
Patients with active cancer, unstable medical conditions, or those currently undergoing fertility treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to recruit 30,000 individuals aged 40-70 and follow them for 25 years to understand variations in disease susceptibility, clinical phenotypes, and therapeutic responses. Participants will visit a Clinical Test Center every two years, undergo phone interviews on alternate years, and provide samples for biobanking. The study will also collect annual online questionnaires to assess the impact of various factors on disease progression. The goal is to evaluate the interplay of omics, physiological characteristics, and lifestyle in disease pathogenesis.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the factors influencing adult diseases, leading to improved prevention and treatment strategies.
How similar studies have gone: While similar longitudinal studies have been conducted, this specific approach focusing on the interplay of various health factors over such an extended period is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18+, males and females. Exclusion Criteria: * Pregnancy. * Mentally disabled or in general legally non-competent. * Prisoner or soldier. Soldiers: mandatory service only * Active cancer * Fertility Treatments (current) * Hepatitis ( B, C), chronic or acute * HIV * Liver cirrhosis * Dialysis * Unstable medical conditions
Where it's running
-
Weizmann institute of science
Rehovot, Israel Recruiting
Study contacts
- Study coordinator: Eran Segal, Prof.
- Email: Eran.Segal@weizmann.ac.il
- Phone: 972-8-9343266
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.