Long-term safety evaluation of ONO-4538 in cancer patients

A Multicenter, Open-label, Phase II Pan-Tumor Study in Patients Who Have Participated in Trials to Investigate Efficacy and Safety of ONO-4538 as Monotherapy or in Combination With Other Therapies and Are Continuing ONO-4538 Treatment (ONO-4538-98)

Phase 2 Interventional Ono Pharmaceutical Co., Ltd. · NCT04566380

This study is testing the long-term safety of the cancer treatment ONO-4538 in patients with different tumors who are already receiving this medication.

Quick facts

PhasePhase 2
Study typeInterventional
Enrollment59 (estimated)
Ages16 Years and up
SexAll
SponsorOno Pharmaceutical Co., Ltd. Industry-sponsored
Locations38 sites (Kashiwa, Chiba and 37 other locations)
Trial IDNCT04566380 on ClinicalTrials.gov

What this trial studies

This study aims to confirm the long-term safety of ONO-4538 in participants with various tumors who are receiving ONO-4538 either alone or in combination with other therapies. Participants must be currently treated with ONO-4538 as part of ongoing clinical trials. The study will monitor the safety profile and any adverse effects associated with the treatment over an extended period.

Who should consider this trial

Good fit: Ideal candidates for this study are patients currently receiving ONO-4538 as part of a clinical trial for their cancer treatment.

Not a fit: Patients who are unable to provide consent due to cognitive impairments or those deemed inappropriate by the investigator will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the long-term safety of ONO-4538, potentially leading to improved treatment options for cancer patients.

How similar studies have performed: Other studies evaluating the safety of similar therapies have shown promising results, indicating that this approach is supported by prior research.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Participant who is being treated with ONO-4538 as monotherapy or in Combination with Other Therapies in clinical trials
2. Participant who is eligible for ONO-4538 monotherapy or in combination with other therapies as per the clinical trials, and/or investigator-assessed clinical benefit

Exclusion Criteria:

1. Participant judged to be incapable of providing consent for reasons such as concurrent dementia
2. Participant judged by the investigator to be inappropriate as participants of this study

Where this trial is running

Kashiwa, Chiba and 37 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Pan-tumor
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.