Long-term recovery and vaccination cost-effectiveness for tick-borne encephalitis in the Czech Republic

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective multicenter observational study enrolling children and adults hospitalized with laboratory-confirmed TBE across major Czech infectious disease centers. Participants receive standardized clinical, functional, and quality-of-life assessments at discharge and at 2–4 weeks, 3 months, 6 months, and 12 months to map recovery trajectories and identify persistent symptoms characterized as post-encephalitic syndrome. Acute disease severity is categorized using predefined clinical criteria including paresis, ICU admission, prolonged hospitalization, or death. The dataset is combined with health-economic analyses to model the potential population-level impact and cost-effectiveness of broader TBE vaccination in this high-incidence setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitalization due to suspected central nervous system (CNS) infection.
* Laboratory-confirmed TBE, defined as:

the presence of CNS symptoms and cerebrospinal fluid pleocytosis (\>5 × 10⁶/L) and TBEV IgM and IgG seropositivity in serum, or detection of TBEV IgM in CSF in previously vaccinated individuals.

* All age groups (children and adults).
* Ability to participate in scheduled follow-up (in person or via telephone).
* Informed consent provided by the patient or legal guardian (for minors).

Exclusion Criteria:

* Alternative diagnosis explaining the CNS symptoms
* Missing essential clinical or laboratory data required to confirm TBE or assess outcomes.
* Refusal or inability to provide informed consent.
* Inability to complete follow-up assessments, including situations where reliable contact cannot be maintained.
* Coexisting severe neurological disorder unrelated to TBE that prevents meaningful evaluation of sequelae (e.g., advanced neurodegenerative disease, severe preexisting motor disability).

Where it's running

• Ostrava University Hospital
  Ostrava, Moravian-Silesian Region, Czechia Recruiting
• Pardubická nemocnice
  Pardubice, Pardubice Region, Czechia Recruiting
• Bulovka University Hospital
  Prague, Prague, Czechia Recruiting
• České Budějovice Hospital
  České Budějovice, South Bohemian Region, Czechia Recruiting

Study contacts

• Study coordinator: Martin Slížek, MD
• Email: martin.slizek89@gmail.com
• Phone: 00420602269494

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.