Long-term physiological changes in children after biliary tract reconstruction
Official title: A Longitudinal Cohort Study on the Changes of Physiological Mechanisms in Children After Biliary Tract Reconstruction
Run by Wuhan Children's Hospital · NCT07530354 · Data updated 2026-11-12
This project will follow children who had biliary tract reconstruction for choledochal cyst to see if early changes in liver, metabolism, or immune function predict health problems later in life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 16 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Wuhan Children's Hospital Academic / other |
| Locations | 3 sites (Wuhan, Hubei and 2 other locations) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | April 2035 |
| Study ends | April 30, 2035 |
| Registry record updated | April 15, 2026 |
| Trial ID | NCT07530354 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children who have undergone biliary tract reconstruction for choledochal cyst, who do not have other major illnesses, and who can attend scheduled follow-up visits are ideal candidates.
✕Probably not a fit
Children with preexisting serious conditions (for example cancer or autoimmune disease), those with obvious liver dysfunction before surgery, or those unable to participate in long-term follow-up are unlikely to benefit from this observational project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a longitudinal observational cohort that follows children after biliary tract reconstruction and compares them with healthy age- and gender-matched controls. Researchers will monitor liver function, metabolic markers, immune responses, and other physiological measures over time and collect data on cognitive and musculoskeletal health. The study will look for biomarkers that link early postoperative changes to adult risks such as liver cirrhosis, diabetes, and cardiovascular disease. Results will be used to propose preventive or early-intervention measures to reduce long-term complications.
Why it matters
Potential benefit: If successful, the study could identify early warning signs and guide interventions that reduce the risk of liver disease, metabolic disorders, and other long-term complications in these patients.
How similar studies have gone: Smaller cohorts have tracked liver outcomes after biliary reconstruction, but comprehensive long-term work linking metabolic, immune, cognitive, and musculoskeletal outcomes is limited, so much of this approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy children matched by age and gender were selected as the control group Exclusion Criteria: * Combined with other serious diseases (such as cancer, autoimmune diseases), having obvious liver function abnormalities before surgery or being undergoing other major treatments.
Where it's running
-
Wuhan Children's Hospital
Wuhan, Hubei, China Recruiting -
Wuhan Children'S Hospital
Wuhan, Hubei, China Recruiting -
Wuhan Children'S Hospital
Wuhan, Hubei, China Recruiting
Study contacts
- Study coordinator: Xueqiang Yan
- Email: yanxueqiang1@163.com
- Phone: +8615871716704
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Surgical options for Type IVa choledochal cyst (biliary dilatation)
This project will compare two surgical approaches to see which gives better short- and long-term outcomes for people with Type IVa choledochal cyst.
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Cohort study on biliary dilatation in China
This study is trying to gather information from patients with bile duct dilatation across China to better understand the condition, its risks, and the best timing for surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.