Long-term outcomes of adolescents with esophageal atresia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create a prospective cohort of adolescents aged 13 and 14 who were born with esophageal atresia in France. It will involve collecting clinical and omic data, including a biobank of esophageal mucosa and plasma blood samples, to assess the long-term outcomes of this rare condition. The data will be analyzed using the France Cohortes information system to establish multi-omic profiles and understand the health issues that persist after surgical intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* For the oesophageal atresia group :
* Born with oesophageal atresia (EA) in France or in French overseas departments and territories
* Anastomosis performed
* Included into the ReNaTo registry
* Aged 13 or 14 during the recruitment period
* Patient willing to comply with all study procedures and duration
* Patient will social security

For the blood sub-study :

* Upper GI endoscopy performed as part of care between 13 and 14 years of age with esophageal mucosal biopsy sampling
* Patient having given written consent to participate in the study

For the control arm:

* Upper GI endoscopy performed as part of care between 10 and 14 years of age with oesophageal mucosal biopsy sampling
* Upper GI endoscopy performed as part of care for chronic or acute digestive signs to rule out organic etiology (peptic esophagitis, gastric esophagitis, eosinophilic esophagitis or ulcer)
* Normal endoscopy and histology
* No chronic progressive disease

Exclusion Criteria:

* For the oesophagal atresia arm :
* Concurrent participation in an interventional trial and in the 3 months prior to inclusion
* Parents refusing to participate in the study

For the control arm :

* Histologically non-normal esophageal biopsy
* Parents refusing to participate in the study
* Child with known organic pathology

Where it's running

• CHU de Lille Hôpital Jeanne de Flandre
  Lille, Nord, France Recruiting
• CHU Angers
  Angers, France Recruiting
• CHU Bordeaux
  Bordeaux, France Recruiting
• HLC Hôpital Mère Enfant
  Bron, France Recruiting
• CHU Caen
  Caen, France Recruiting
• CHI Créteil
  Créteil, France Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Balloon inflation time for esophageal narrowing after atresia repair

  This trial will try different balloon inflation times during endoscopic dilation to see which works best for children with narrowing after esophageal atresia repair.

  Recruiting at 2 sites Boston Children's Hospital · Boston, Massachusetts and 1 other locations · NCT07100379

• Comparing physical health in children with esophageal atresia and healthy peers

  This study looks at how the physical health of children with esophageal atresia compares to that of healthy kids to see how the condition affects things like strength, exercise, and overall well-being.

  Recruiting Hacettepe University · Ankara, Ankara · NCT06975982

• Evaluation of follow-up care for adults with esophageal atresia

  This study is testing a new follow-up care program for adults with esophageal atresia to see if it helps improve their overall quality of life and manage issues like PTSD.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06860919

• Camera-based Endoscopy to Manage Airway in Neonates with Tracheoesophageal Fistula

  This observation compares rigid tracheoscopy with flexible tracheo-video-endoscopy in newborns needing pre-repair airway assessment for tracheoesophageal fistula.

  Recruiting Papa Giovanni XXIII Hospital · Bergamo, Italy · NCT07687628

• How being told before versus after birth affects parents' post‑traumatic reactions after their baby's esophageal atresia surgery

  The study will see if parents who learn about their baby's esophageal atresia before birth have different levels of post‑traumatic reactions than parents who learn after birth, focusing mainly on mothers (with fathers invited to participate) of children aged 12–24 months who had neonatal surgery.

  Recruiting University Hospital, Lille · Lille · NCT04911036

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.