Long-term health follow-up of premature infants
Official title: A Cohort Study on the Long-term Health Outcomes of Premature Infants
Run by Shanghai Children's Medical Center · NCT05017389 · Data updated 2026-11-12
This study is looking at the long-term health of preterm infants to see how their early experiences affect their growth and development over 18 years.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 15 Days to 4 Months |
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | Shanghai Children's Medical Center Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | December 31, 2023 |
| Study ends | December 31, 2041 |
| Registry record updated | August 23, 2021 |
| Trial ID | NCT05017389 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are live-born newborns with a gestational age of 36 weeks and 6 days or less, who are admitted to the neonatal ward within 24 hours of birth and plan to reside in Shanghai long-term.
✕Probably not a fit
Patients who have major congenital malformations or whose treatment is terminated for non-disease reasons may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational cohort study aims to establish a comprehensive database for the long-term health and development of preterm infants. It will collect clinical diagnosis, treatment, and follow-up data from approximately 1200 preterm infants admitted to the neonatal department over three years and follow them for 18 years. The study will analyze the impact of prenatal factors, postnatal treatment, and family environment on the health outcomes of these infants, including survival rates and the development of chronic diseases. The findings will help improve treatment plans and identify potential therapeutic targets.
Why it matters
Potential benefit: If successful, this study could significantly enhance the understanding and management of long-term health issues in preterm infants.
How similar studies have gone: Other studies have shown success in similar cohort approaches, indicating the potential for valuable insights into the long-term health of preterm infants.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Live born newborns with gestational age ≤ 36 + 6 weeks 2. Transfer to the neonatal ward of Shanghai Children's medical center within 24 hours after birth 3. Those who have lived in Shanghai for more than 1 year and plan to live in Shanghai for a long time. Parents voluntarily participated in the study and signed informed consent Exclusion Criteria: 1. Premature infants: termination of treatment due to family factors (non-disease reasons) and hospitalization time ≤ 2 weeks 2. Major congenital malformations 3. Parents refuse to participate in the study
Where it's running
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Shanghai children's medical center
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Shumei Dong, master
- Email: dongshumei@scmc.com.cn
- Phone: 38626161
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Premature infants: trying PIOMI with mom to support feeding
Aims to see if PIOMI done with a mother’s presence and voice helps preterm babies feed better and feel more connected to mom.
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SAFE early intervention for high-risk infants to support arm function
This randomized trial tests whether the SAFE early intervention helps improve upper limb function and early development in high-risk infants aged 3–12 months compared with standard Neurodevelopmental Treatment (NDT).
-
PIMUN to reduce low-oxygen episodes in preterm infants
We will test whether PIMUN, a soft garment that gives gentle pulsatile dorsal stimulation, can reduce low-oxygen (SpO2 <90%) episodes in preterm infants born at 24–34 weeks who have apnea of prematurity.
-
Cerclage plus progesterone versus progesterone alone for twins with a short cervix
This will test whether adding a cervical stitch (cerclage) to progesterone helps prevent early birth in people carrying twins who have a short cervix (≤30 mm).
-
Helping preterm babies learn to feed using scheduled pacifier use
This study tests whether giving preterm babies a 5-minute pacifier before each feeding versus a 30-minute pacifier at random times helps them develop feeding skills faster and leave the hospital sooner.
-
Early physiotherapy to improve motor optimality in at-risk infants
This trial will test whether starting a targeted physiotherapy program early improves motor movement scores in infants born preterm or who had serious neonatal complications.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.