Long-term follow-up of patients with joint issues after Chikungunya infection
Post-Chikungunya Rheumatism - Rheumatology Follow-up of Patients After 15 Years
This study is looking to see how joint problems caused by Chikungunya infection have changed over 15 years in people who were originally assessed after a severe outbreak.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 220 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 3 sites (Saint-Denis and 2 other locations) |
| Trial ID | NCT04838574 on ClinicalTrials.gov |
What this trial studies
This observational study aims to re-evaluate patients who were part of the RHUMATOCHIK cohort, originally assessed two months after a severe Chikungunya outbreak in Reunion Island. After 15 years, the study will systematically classify and describe the spectrum of persistent Chikungunya-related joint diseases through clinical rheumatologic examinations. The study seeks to address previous limitations by including a larger and more representative population to better understand long-term outcomes. Participants will undergo a telephone interview and screening questionnaire prior to the clinical evaluation.
Who should consider this trial
Good fit: Ideal candidates include individuals who were previously part of the RHUMATOCHIK study or diagnosed with Chikungunya-related Rheumatoid Arthritis.
Not a fit: Patients with pre-existing chronic inflammatory rheumatic diseases prior to Chikungunya infection or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the long-term management and treatment of Chikungunya-related joint diseases.
How similar studies have performed: While there have been studies on Chikungunya-related symptoms, this study's long-term follow-up approach is relatively novel and aims to fill gaps in existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients previously included in the RHUMATOCHIK study (N=307), or diagnosed as Chikungunya-related Rheumatoid Arthritis (N=21) after telephonic screening and given their oral consent * Chikungunya infection (positive serology and/or evocative symptoms in the epidemic context) Exclusion Criteria: * Impossible informed consent (cognitive impairment,...). * Lost-to-follow-up patients, refusal to participate. -Pre-existing chronic inflammatory rheumatic disease (prior to CHIKV infection)-
Where this trial is running
Saint-Denis and 2 other locations
- CHU La Réunion (Nord) — Saint-Denis, Réunion (Recruiting)
- CH Ouest Réunion — Saint-Paul, Réunion (Not_yet_recruiting)
- CHU La Réunion (Sud) — Saint-Pierre, Réunion (Recruiting)
Study contacts
- Study coordinator: Xavier GUILLOT
- Email: xavier.guillot@chu-reunion.fr
- Phone: 0262 90 59 20
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.