Long-term follow-up of Korean CADASIL patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

K-CADASIL is a nationwide, multicenter prospective cohort that will enroll roughly 500 Korean adults with suspected or genetically confirmed CADASIL and follow them for 10 years. Participants will undergo regular clinic visits with neurological exams, MRI brain imaging, blood sampling, and standardized neuropsychological testing. Collected samples and data will form a genomic and proteomic biorepository to enable future multi-omics analyses. The program aims to link clinical features, imaging changes, comorbidities, and molecular markers to long-term outcomes in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 19 years
* CADASIL suspected or confirmed by genetic testing (NOTCH3 mutation)
* Able to provide written informed consent (participant or legally authorized representative)

Exclusion Criteria:

* Contraindication to MRI (claustrophobia, metal implants, pacemaker)
* Acute ischemic or hemorrhagic stroke within 180 days prior to enrollment

Where it's running

• Jeju National University Hospital
  Jeju City, Jeju-do, South Korea Recruiting

Study contacts

• Study coordinator: Jay Chol Professor Choi, MD, PhD, MD, PhD
• Email: jaychoi@jejunu.ac.kr
• Phone: +82-64-754-8160

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Analyzing genetic and imaging features in CADASIL patients

  This study is trying to see how genetic and brain imaging information can help doctors better understand and treat CADASIL in patients with specific genetic markers.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan and 1 other locations · NCT06938100

• Establishing an Australian cohort of CADASIL patients

  This study is trying to gather information from Australian patients with CADASIL to better understand how the condition affects them over time.

  Recruiting at 4 sites The University of New South Wales · Newcastle, New South Wales and 4 other locations · NCT06148051

• Understanding the prognosis of cerebral small vessel disease

  This study looks at how different types of cerebral small vessel disease affect the health and future outcomes of patients, including issues like bleeding in the brain and memory problems.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT05734378

• Understanding CADASIL and its effects on cognitive impairment

  This study is trying to understand how CADASIL affects thinking and memory over time in people with a family history of the condition.

  Recruiting at 10 sites University of Wisconsin, Madison · Los Angeles, California and 11 other locations · NCT05677880

• Investigating genetic and non-genetic factors in small vessel disease

  This study is trying to see how genetic and non-genetic factors affect people with small vessel disease in the brain by looking at their symptoms and MRI results over two years.

  Recruiting National Taiwan University Hospital · Taipei · NCT05473637

• Registry for CADASIL patients and their relatives

  This study is trying to learn more about CADASIL and how it affects patients and their families to improve care and understanding of the condition.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT04310098

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.