Long-term follow-up of endocrine and metabolic changes after gestational diabetes
Official title: Long-Term Effects of Gestational Diabetes Mellitus on Postpartum Chronic Non-Communicable Diseases: A Prospective Cohort Study
Run by Peking University First Hospital · NCT07119177 · Data updated 2026-11-12
This project will follow women who had gestational diabetes and their children to see if pregnancy and early-life measurements predict later chronic diseases.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 800 (estimated) |
| Sponsor | Peking University First Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | March 29, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 12, 2025 |
| Trial ID | NCT07119177 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) who registered for antenatal care and delivered at Peking University First Hospital between 2007 and 2016, were diagnosed with GDM by OGTT, and can provide informed consent and attend follow-up visits are ideal candidates.
✕Probably not a fit
People without complete pregnancy records, those unable to complete follow-up, those not diagnosed with GDM, or individuals who delivered elsewhere are unlikely to gain direct benefit from this cohort's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort will enroll women aged 18 and older who delivered at Peking University First Hospital between 2007 and 2016 and had GDM diagnosed by OGTT. Investigators will combine antenatal records, diagnostic OGTT data, and scheduled long-term follow-ups to track endocrine, metabolic, and clinical outcomes in mothers and their offspring. The project aims to map the natural course of non-communicable chronic diseases after GDM, identify high-risk factors and key mediators, and build predictive models for timing and targets of intervention. No interventional procedures are planned; analyses will be observational and data-driven to inform future prevention strategies.
Why it matters
Potential benefit: If successful, this work could identify mothers and children at high risk for diabetes, obesity, and other chronic diseases and support earlier, more targeted prevention efforts.
How similar studies have gone: Previous cohorts have associated GDM with higher maternal and offspring risk of diabetes and obesity, but large, long-term, high-quality cohorts and validated predictive models remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥18 years old) who registered for antenatal care and delivered at Peking University Firest Hospital's obstetrics department between 2007 and 2016. * Diagnosed with gestational diabetes mellitus (GDM) during pregnancy via an oral glucose tolerance test (OGTT). * Signed informed consent. Exclusion Criteria: * Lack of pregnancy-related obstetric follow-up records. * Inability to cooperate with and complete subsequent scheduled follow-ups.
Where it's running
-
Peking University First Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: YANG ZHANG, Doctor
- Email: emilyzy14@sina.com
- Phone: 008601083575103
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.