Long-term follow-up of endocrine and metabolic changes after gestational diabetes
Long-Term Effects of Gestational Diabetes Mellitus on Postpartum Chronic Non-Communicable Diseases: A Prospective Cohort Study
This project will follow women who had gestational diabetes and their children to see if pregnancy and early-life measurements predict later chronic diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Peking University First Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT07119177 on ClinicalTrials.gov |
What this trial studies
This prospective cohort will enroll women aged 18 and older who delivered at Peking University First Hospital between 2007 and 2016 and had GDM diagnosed by OGTT. Investigators will combine antenatal records, diagnostic OGTT data, and scheduled long-term follow-ups to track endocrine, metabolic, and clinical outcomes in mothers and their offspring. The project aims to map the natural course of non-communicable chronic diseases after GDM, identify high-risk factors and key mediators, and build predictive models for timing and targets of intervention. No interventional procedures are planned; analyses will be observational and data-driven to inform future prevention strategies.
Who should consider this trial
Good fit: Adults (≥18 years) who registered for antenatal care and delivered at Peking University First Hospital between 2007 and 2016, were diagnosed with GDM by OGTT, and can provide informed consent and attend follow-up visits are ideal candidates.
Not a fit: People without complete pregnancy records, those unable to complete follow-up, those not diagnosed with GDM, or individuals who delivered elsewhere are unlikely to gain direct benefit from this cohort's findings.
Why it matters
Potential benefit: If successful, this work could identify mothers and children at high risk for diabetes, obesity, and other chronic diseases and support earlier, more targeted prevention efforts.
How similar studies have performed: Previous cohorts have associated GDM with higher maternal and offspring risk of diabetes and obesity, but large, long-term, high-quality cohorts and validated predictive models remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥18 years old) who registered for antenatal care and delivered at Peking University Firest Hospital's obstetrics department between 2007 and 2016. * Diagnosed with gestational diabetes mellitus (GDM) during pregnancy via an oral glucose tolerance test (OGTT). * Signed informed consent. Exclusion Criteria: * Lack of pregnancy-related obstetric follow-up records. * Inability to cooperate with and complete subsequent scheduled follow-ups.
Where this trial is running
Beijing, Beijing Municipality
- Peking University First Hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: YANG ZHANG, Doctor
- Email: emilyzy14@sina.com
- Phone: 008601083575103
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.