Clinical trial Recruiting at 1 site Observational Ages 18 and up

Long-term follow-up of depression in psychiatric care

Official title: 5 Years Follow-up of the Study: "Pharmacogenetics in Depressed Patients With Specific Focus on Difficult-to-treat Depresssion, Suicide Attempt and CYP2D6"

Run by Region Skane · NCT07078227 · Data updated 2026-11-12

This project will follow 415 people with difficult-to-treat depression who were previously studied to see how their symptoms and treatment outcomes change over five years.

More Depression trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment415 (estimated)
SponsorRegion Skane
Academic / other
Locations2 sites (Lund and 1 other locations)
StatusRecruiting
StartedJune 1, 2025
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedApril 30, 2026
Trial IDNCT07078227 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people who participated in the original pharmacogenetics study of difficult-to-treat depression and consent to follow-up via medical records and register linkage.

Probably not a fit

People who were not part of the original cohort or who do not consent to record access will not be included and therefore will not benefit from this follow-up.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will re-contact a cohort of 415 patients recruited between 2012 and 2021 who had detailed diagnostic interviews and were genotyped for CYP2D6 and CYP2C19. No new treatments are given; the team will extract clinical data from medical records and national registers for a five-year period after the original participation. Stored blood samples in a biobank allow future biomarker analyses linked to prognosis. The aim is to identify clinical and genetic predictors of long-term course and treatment outcomes in difficult-to-treat depression.

Why it matters

Potential benefit: If successful, the findings could help clinicians predict who is more likely to recover or relapse and tailor medication choices based on clinical and genetic markers.

How similar studies have gone: Previous long-term observational cohorts and pharmacogenetic studies have yielded useful, mostly incremental insights into prognosis and medication response but have not produced definitive treatment algorithms.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Participation in the study "Pharmacogenetics in depressive patients with specific focus on difficult-to-treat depression, suicide attempt and CYP2D6"

Exclusion Criteria:

Not wanting to participate in the follow-up study

Where it's running

  • Research Unit, Office of Psychiatricy, habilitation and technical aid
    Lund, Sweden
    Recruiting
  • Psychiatry Reserach Unit
    Lund, Sweden
    Active not recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.