Long-term follow-up for chronic hepatitis B patients treated with imdusiran

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the long-term follow-up of chronic hepatitis B (CHB) patients who previously received imdusiran treatment and have stopped nucleos(t)ide analog (NA) therapy. Participants will be monitored for approximately two years after completing their prior clinical trial, during which no new interventions will be administered. The study will involve blood sample collections, medication reviews, and reporting of any adverse events related to study procedures or NA therapy if it is restarted. The goal is to gather data on the long-term effects of imdusiran treatment in these patients.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

* Have participated in a prior imdusiran clinical trial,
* Have discontinued NA therapy in that trial and remain off NA therapy,
* Have completed less than 3 years of follow-up visits after NA discontinuation in the parent study.
* Have the ability to review and provide signed informed consent which includes compliance with all protocol-specified visit schedules and requirements.

Exclusion Criteria:

* Not applicable

Where it's running

• Research and Education Inc.
  San Diego, California, United States Recruiting
• Infectious Disease Care
  Hillsborough, New Jersey, United States Recruiting
• The Alfred Hospital
  Melbourne, Victoria, Australia Recruiting
• Prince of Wales Hospital
  Shatin, New Territories, Hong Kong Recruiting
• Queen Mary Hospital
  Hong Kong, Hong Kong Recruiting
• Arensia Exploratory Medicine Moldova
  Chisinau, Moldova Recruiting

Study contacts

• Study coordinator: Michael Child
• Email: mchild@arbutusbio.com
• Phone: 267-332-6213

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.