Long-term effects of childhood solid tumors and their treatments in survivors
Official title: Constitution d'Une Cohorte Nationale rétrospective de Survivants d'un Cancer Solide de l'Enfant diagnostiqué Avant 2000
Run by Institut National de la Santé Et de la Recherche Médicale, France · NCT01620372 · Data updated 2026-11-12
This study looks at the long-term health and quality of life of childhood cancer survivors treated for solid tumors in France to see how their past treatments affect them now.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 18000 (estimated) |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 36 sites (Amiens and 35 other locations) |
| Status | Recruiting |
| Started | November 15, 2011 |
| Main results expected | November 15, 2031 |
| Study ends | November 15, 2031 |
| Registry record updated | July 30, 2026 |
| Trial ID | NCT01620372 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals who were diagnosed with any type of solid childhood cancer in France before the age of 19 between 1942 and 1999.
✕Probably not a fit
Patients diagnosed with leukemia will not benefit from this study as they are excluded from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The French Childhood Cancer Survivor Study (FCCSS) is a large-scale observational study that focuses on children treated for solid tumors in France before the year 2000. It aims to improve understanding of the long-term health and social outcomes of these survivors, including the risk of second malignancies and other health issues related to cancer treatments. The study will follow a cohort of survivors for up to 20 years, utilizing medical records, national registries, and self-questionnaires to gather comprehensive data on their health and quality of life. By identifying high-risk patients and comparing their mortality rates with the general population, the FCCSS seeks to inform better follow-up care and preventive measures.
Why it matters
Potential benefit: If successful, this study could lead to improved long-term care and monitoring strategies for childhood cancer survivors, enhancing their quality of life.
How similar studies have gone: Other studies have shown success in understanding long-term effects of childhood cancer treatments, making this approach both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All types of solid childhood cancer in France * Age at diagnosis: Below age 19 * Period of diagnosis: between 1st January 1942 and 31st December 1999 * Complete identification (first name, last name, date of birth and place of birth) Exclusion Criteria: * Leukaemia cases
Where it's running
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Centre Antoine Lacassagne
Nice, France Recruiting -
Institut Curie
Paris, France Recruiting -
Institut Jean Godinot
Reims, France Recruiting -
Institut Claudius Regaud
Toulouse, France Recruiting -
Institut Gustave Roussy
Villejuif, France Recruiting -
Centre Hospital-Universitaire Hôpital Nord
Amiens, France Active not recruiting
Show 30 more locations
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Centre Hospitalier-Universitaire
Angers, France Active not recruiting -
Centre Hospitalier Régional Universitaire Hôpital Saint-Jacques
Besançon, France Active not recruiting -
Groupe hospitalier Pellegrin
Bordeaux, France Active not recruiting -
Centre Hospitalier Universaitaire Hôpital Côte de Nacre
Caen, France Active not recruiting -
Centre Hospitalier Universitaire Hôpial Hôtel Dieu
Clermont-Ferrand, France Active not recruiting -
Centre Hospitalier Universaitaire hôpital d'enfants
Dijon, France Active not recruiting -
Hôpital La Tronche
Grenoble, France Active not recruiting -
Centre Oscar Lambret
Lille, France Active not recruiting -
Hôpital Jeanne De Flandre
Lille, France Active not recruiting -
Hôpital de la mère et de l'enfant
Limoges, France Active not recruiting -
Institut d'Hématologie et Oncologie Pédiatrique
Lyon, France Active not recruiting -
Centre Régional de Lutte Contre le Cancer Centre Léon Bérard
Lyon, France Active not recruiting -
Hôpital d'Enfants de Margency (HEM) Croix Rouge Française
Margency, France Active not recruiting -
AP-HM Hôpital de la Timone
Marseille, France Active not recruiting -
Hôpital Arnaud De Villeneuve
Montpellier, France Active not recruiting -
Centre Hospitalier Universaitaire Hôpital mère-enfant
Nantes, France Active not recruiting -
GCS Hôpitaux pédiatriques Centre Hospitalier Universitaire Lenval
Nice, France Active not recruiting -
Hôpital Armand Trousseau
Paris, France Active not recruiting -
CHRU de Poitiers La Miletrie
Poitiers, France Active not recruiting -
Centre Hospitalier Universitaire de Reims Hôpital Maison Blanche
Reims, France Active not recruiting -
Centre Hospitalier Universitaire Hôpital Sud
Rennes, France Active not recruiting -
Hôpital Charles-Nicolle
Rouen, France Active not recruiting -
Centre Hospitalier Universitaire Hôpital Nord
Saint-Etienne, France Active not recruiting -
Centre René Gauducheau de Nantes Atlantique
Saint-Herblain, France Active not recruiting -
Centre Hospitalier de Saintonge
Saintes, France Active not recruiting -
Hôpital Hautepierre
Strasbourg, France Active not recruiting -
Hôpital des Enfants
Toulouse, France Active not recruiting -
Hôpital Clocheville
Tours, France Active not recruiting -
Hôpital Brabois enfants CHU de Nancy
Vandœuvre-lès-Nancy, France Active not recruiting -
Centre Régional de Lutte Contre le Cancer de Lorraine ALEXIS VAUTRIN
Vandœuvre-lès-Nancy, France Active not recruiting
Study contacts
- Principal investigator: Florent F. de Vathaire, Ph.D. — Institut National de la Santé Et de la Recherche Médicale, France
- Study coordinator: Florent F. de Vathaire, Ph.D
- Email: florent.devathaire@igr.fr
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Targeted therapies for childhood and adolescent cancer
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-
Precision medicine for children with cancer
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This study is testing if a new drug called Nivolumab can help prevent or delay the return of high-risk sarcomas in children and adults after they receive a special type of bone marrow transplant.
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Collecting and storing tissue samples from patients with suspected solid tumors
This study is collecting blood and tissue samples from patients with suspected solid tumors to help with future cancer research and understand how normal tissue changes to cancerous tissue.
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Quality of End-of-Life Care for Children With Cancer
This study looks at how access to care, family interactions with the healthcare system, and stress relate to the quality of end-of-life care for children with cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.