Clinical trial Recruiting at 5 sites Observational Ages Any age to 18

Long-term effects of childhood solid tumors and their treatments in survivors

Official title: Constitution d'Une Cohorte Nationale rétrospective de Survivants d'un Cancer Solide de l'Enfant diagnostiqué Avant 2000

Run by Institut National de la Santé Et de la Recherche Médicale, France · NCT01620372 · Data updated 2026-11-12

This study looks at the long-term health and quality of life of childhood cancer survivors treated for solid tumors in France to see how their past treatments affect them now.

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Quick facts

Study typeObservational
AgesAny age to 18 Years
SexAll
Enrollment18000 (estimated)
SponsorInstitut National de la Santé Et de la Recherche Médicale, France
Government
Drugs / interventionschemotherapy, radiation
Locations36 sites (Amiens and 35 other locations)
StatusRecruiting
StartedNovember 15, 2011
Main results expectedNovember 15, 2031
Study endsNovember 15, 2031
Registry record updatedJuly 30, 2026
Trial IDNCT01620372 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals who were diagnosed with any type of solid childhood cancer in France before the age of 19 between 1942 and 1999.

Probably not a fit

Patients diagnosed with leukemia will not benefit from this study as they are excluded from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The French Childhood Cancer Survivor Study (FCCSS) is a large-scale observational study that focuses on children treated for solid tumors in France before the year 2000. It aims to improve understanding of the long-term health and social outcomes of these survivors, including the risk of second malignancies and other health issues related to cancer treatments. The study will follow a cohort of survivors for up to 20 years, utilizing medical records, national registries, and self-questionnaires to gather comprehensive data on their health and quality of life. By identifying high-risk patients and comparing their mortality rates with the general population, the FCCSS seeks to inform better follow-up care and preventive measures.

Why it matters

Potential benefit: If successful, this study could lead to improved long-term care and monitoring strategies for childhood cancer survivors, enhancing their quality of life.

How similar studies have gone: Other studies have shown success in understanding long-term effects of childhood cancer treatments, making this approach both relevant and necessary.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All types of solid childhood cancer in France
* Age at diagnosis: Below age 19
* Period of diagnosis: between 1st January 1942 and 31st December 1999
* Complete identification (first name, last name, date of birth and place of birth)

Exclusion Criteria:

* Leukaemia cases

Where it's running

  • Centre Antoine Lacassagne
    Nice, France
    Recruiting
  • Institut Curie
    Paris, France
    Recruiting
  • Institut Jean Godinot
    Reims, France
    Recruiting
  • Institut Claudius Regaud
    Toulouse, France
    Recruiting
  • Institut Gustave Roussy
    Villejuif, France
    Recruiting
  • Centre Hospital-Universitaire Hôpital Nord
    Amiens, France
    Active not recruiting
Show 30 more locations
  • Centre Hospitalier-Universitaire
    Angers, France
    Active not recruiting
  • Centre Hospitalier Régional Universitaire Hôpital Saint-Jacques
    Besançon, France
    Active not recruiting
  • Groupe hospitalier Pellegrin
    Bordeaux, France
    Active not recruiting
  • Centre Hospitalier Universaitaire Hôpital Côte de Nacre
    Caen, France
    Active not recruiting
  • Centre Hospitalier Universitaire Hôpial Hôtel Dieu
    Clermont-Ferrand, France
    Active not recruiting
  • Centre Hospitalier Universaitaire hôpital d'enfants
    Dijon, France
    Active not recruiting
  • Hôpital La Tronche
    Grenoble, France
    Active not recruiting
  • Centre Oscar Lambret
    Lille, France
    Active not recruiting
  • Hôpital Jeanne De Flandre
    Lille, France
    Active not recruiting
  • Hôpital de la mère et de l'enfant
    Limoges, France
    Active not recruiting
  • Institut d'Hématologie et Oncologie Pédiatrique
    Lyon, France
    Active not recruiting
  • Centre Régional de Lutte Contre le Cancer Centre Léon Bérard
    Lyon, France
    Active not recruiting
  • Hôpital d'Enfants de Margency (HEM) Croix Rouge Française
    Margency, France
    Active not recruiting
  • AP-HM Hôpital de la Timone
    Marseille, France
    Active not recruiting
  • Hôpital Arnaud De Villeneuve
    Montpellier, France
    Active not recruiting
  • Centre Hospitalier Universaitaire Hôpital mère-enfant
    Nantes, France
    Active not recruiting
  • GCS Hôpitaux pédiatriques Centre Hospitalier Universitaire Lenval
    Nice, France
    Active not recruiting
  • Hôpital Armand Trousseau
    Paris, France
    Active not recruiting
  • CHRU de Poitiers La Miletrie
    Poitiers, France
    Active not recruiting
  • Centre Hospitalier Universitaire de Reims Hôpital Maison Blanche
    Reims, France
    Active not recruiting
  • Centre Hospitalier Universitaire Hôpital Sud
    Rennes, France
    Active not recruiting
  • Hôpital Charles-Nicolle
    Rouen, France
    Active not recruiting
  • Centre Hospitalier Universitaire Hôpital Nord
    Saint-Etienne, France
    Active not recruiting
  • Centre René Gauducheau de Nantes Atlantique
    Saint-Herblain, France
    Active not recruiting
  • Centre Hospitalier de Saintonge
    Saintes, France
    Active not recruiting
  • Hôpital Hautepierre
    Strasbourg, France
    Active not recruiting
  • Hôpital des Enfants
    Toulouse, France
    Active not recruiting
  • Hôpital Clocheville
    Tours, France
    Active not recruiting
  • Hôpital Brabois enfants CHU de Nancy
    Vandœuvre-lès-Nancy, France
    Active not recruiting
  • Centre Régional de Lutte Contre le Cancer de Lorraine ALEXIS VAUTRIN
    Vandœuvre-lès-Nancy, France
    Active not recruiting

Study contacts

  • Principal investigator: Florent F. de Vathaire, Ph.D. — Institut National de la Santé Et de la Recherche Médicale, France
  • Study coordinator: Florent F. de Vathaire, Ph.D
  • Email: florent.devathaire@igr.fr

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Targeted therapies for childhood and adolescent cancer

    This study is testing if new targeted treatments based on the genetic makeup of tumors can help kids and teens with cancer feel better and improve their chances of recovery.

    Recruiting at 12 sites Phase 1/2 Australian & New Zealand Children's Haematology/Oncology Group · Newcastle, New South Wales and 13 other locations · NCT06208657

  • Precision medicine for children with cancer

    This study is testing if personalized medicine can improve treatment and outcomes for children with different types of cancer in Australia and New Zealand.

    Recruiting at 10 sites Australian & New Zealand Children's Haematology/Oncology Group · Adelaide and 10 other locations · NCT05504772

  • Exploring immune responses to cell therapy in tumors

    This study is testing how the immune system reacts to a new cell therapy in patients with different types of tumors to see if these reactions can help predict how well the treatment works and what side effects might occur.

    Recruiting Gustave Roussy, Cancer Campus, Grand Paris · Villejuif, Val de Marne · NCT05481502

  • Using Nivolumab after Half-Matched Bone Marrow Transplant for Sarcoma

    This study is testing if a new drug called Nivolumab can help prevent or delay the return of high-risk sarcomas in children and adults after they receive a special type of bone marrow transplant.

    Recruiting at 3 sites Phase 1/2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · St. Petersburg, Florida and 3 other locations · NCT03465592

  • Collecting and storing tissue samples from patients with suspected solid tumors

    This study is collecting blood and tissue samples from patients with suspected solid tumors to help with future cancer research and understand how normal tissue changes to cancerous tissue.

    Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT00900471

  • Quality of End-of-Life Care for Children With Cancer

    This study looks at how access to care, family interactions with the healthcare system, and stress relate to the quality of end-of-life care for children with cancer.

    Recruiting at 28 sites Children's Oncology Group · Birmingham, Alabama and 27 other locations · NCT07412002

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.