Long-term brain stimulation for older adults with mild cognitive issues
Efficacy of a 24-week Long Term Transcranial Pulse Stimulation (TPS) on Cognition and Brain Structure in Older Adults With Mild Neurocognitive Disorder (NCD)
NA · The University of Hong Kong · NCT05602467
This study is testing if a new brain stimulation method can help older adults with mild cognitive issues slow down their memory decline while they continue their regular treatment.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 22 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | The University of Hong Kong (other) |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT05602467 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of Transcranial Pulse Stimulation (TPS) on older adults diagnosed with mild neurocognitive disorder (NCD). It aims to explore the potential of TPS, a non-invasive brain stimulation technique, to prevent or delay cognitive decline. Participants will receive TPS alongside their usual treatment, with careful monitoring of their cognitive function over time. The study is designed to provide insights into the efficacy of TPS as an alternative intervention for mild NCD.
Who should consider this trial
Good fit: Ideal candidates are Chinese adults aged 60 and above who meet the criteria for mild neurocognitive disorder.
Not a fit: Patients with major neurocognitive disorder, significant medical conditions, or those with certain neurological issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could offer a new non-pharmacological treatment option to help preserve cognitive function in older adults.
How similar studies have performed: While TPS is a newer approach, other non-invasive brain stimulation techniques have shown promise in similar contexts, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 60 years of age or above 2. Chinese ethnicity 3. Fulfil the criteria of mild neurocognitive disorder (NCD), defined by the DSM-5 4. Stable dosage/frequency of anti-dementia therapy or other treatments for mild NCD in recent 8 weeks 5. Valid informed written consent Exclusion Criteria: 1. HK-MoCA score below the second percentile according to the subject's age and education level (to exclude subjects with existing major NCD/dementia) 2. Alcohol or substance dependence 3. Concomitant unstable major medical conditions or major neurological conditions such as brain tumour, recent stroke 4. Haemophilia or other blood clotting disorders or thrombosis 5. Significant communicative impairments 6. Participants with any metal implant in brain or treated area of the head
Where this trial is running
Hong Kong
- The Hong Kong Jockey Club Building for Interdisciplinary Research — Hong Kong, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Calvin PW Cheng, MBBS (HKU) — The University of Hong Kong
- Study coordinator: Calvin PW Cheng, MBBS (HKU)
- Email: chengpsy@hku.hk
- Phone: +852-22554486
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mild Neurocognitive Disorder, TPS, Transcranial Pulse Stimulation, Open-Label, long term intervention