Local vitamin D3 plus corticision to speed up upper canine movement
Official title: Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study
Run by Al-Azhar University · NCT07455656 · Data updated 2026-11-12
This test will try to see if locally applied vitamin D3 together with a minor bone-cutting technique called corticision can speed upper canine retraction in 13–20-year-olds having their upper first premolars removed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 13 Years to 20 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | August 1, 2026 |
| Study ends | August 1, 2027 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT07455656 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy patients aged 13–20 with fully erupted permanent teeth who need bilateral maxillary first premolar extractions (for example, Class II division 1 with crowding or bimaxillary protrusion) and have not had prior orthodontic treatment.
✕Probably not a fit
Patients with impacted canines, severe crowding, untreated decay or endodontic lesions, or systemic diseases or medications affecting tooth movement (such as thyroid, parathyroid, renal, or liver disorders) are unlikely to be eligible or to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective clinical study of adolescents and young adults (ages 13–20) who require bilateral maxillary first premolar extraction and orthodontic canine retraction. Participants will receive local application of vitamin D3 combined with corticision during the retraction phase, and measurements of canine movement and alveolar bone changes will be taken over time. Outcomes will be compared using an independent t-test or a nonparametric equivalent to determine differences in rate of movement and bone response. Safety and any adverse effects will also be monitored throughout follow-up.
Why it matters
Potential benefit: If successful, the approach could shorten orthodontic treatment time and reduce complications linked to longer appliance wear.
How similar studies have gone: Previous randomized trials have shown that vitamin D can accelerate canine distalization and influence alveolar bone density, while the combination of vitamin D with corticision is less well studied and is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Orthodontic patients referred for therapeutic extraction of bilateral maxillary first premolars (Angle Class II division 1 cases, with crowding and bimaxillary protrusion). 2. Fully erupted permanent teeth (except third molar). 3. Age 13-20 patients. 4. No previous orthodontic treatment. 5. Good oral and general health. 6. No systemic disease or regular medication that could interfere with and/or affect orthodontic teeth movement. Exclusion criteria: 1. Patients with impacted canines. 2. Patients with severe crowding. 3. Patients with untreated decay or any endodontic lesions. 4. Patients with thyroid, parathyroid, or renal and liver disease.
Where it's running
-
Orthodontic Outpatient Clinic, Faculty of Dental Medicine, Al-Azhar University
Cairo, Cairo Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Mahmoud Elsaid Elsayed E Mahmoud Elsaid, BDS
- Email: mahmoud_elsaid@azhar.edu.eg
- Phone: +201003221008
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.