Local vitamin D3 plus corticision to speed up upper canine movement
Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study
This test will try to see if locally applied vitamin D3 together with a minor bone-cutting technique called corticision can speed upper canine retraction in 13–20-year-olds having their upper first premolars removed.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 13 Years to 20 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Trial ID | NCT07455656 on ClinicalTrials.gov |
What this trial studies
This is a prospective clinical study of adolescents and young adults (ages 13–20) who require bilateral maxillary first premolar extraction and orthodontic canine retraction. Participants will receive local application of vitamin D3 combined with corticision during the retraction phase, and measurements of canine movement and alveolar bone changes will be taken over time. Outcomes will be compared using an independent t-test or a nonparametric equivalent to determine differences in rate of movement and bone response. Safety and any adverse effects will also be monitored throughout follow-up.
Who should consider this trial
Good fit: Ideal candidates are healthy patients aged 13–20 with fully erupted permanent teeth who need bilateral maxillary first premolar extractions (for example, Class II division 1 with crowding or bimaxillary protrusion) and have not had prior orthodontic treatment.
Not a fit: Patients with impacted canines, severe crowding, untreated decay or endodontic lesions, or systemic diseases or medications affecting tooth movement (such as thyroid, parathyroid, renal, or liver disorders) are unlikely to be eligible or to benefit.
Why it matters
Potential benefit: If successful, the approach could shorten orthodontic treatment time and reduce complications linked to longer appliance wear.
How similar studies have performed: Previous randomized trials have shown that vitamin D can accelerate canine distalization and influence alveolar bone density, while the combination of vitamin D with corticision is less well studied and is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Orthodontic patients referred for therapeutic extraction of bilateral maxillary first premolars (Angle Class II division 1 cases, with crowding and bimaxillary protrusion). 2. Fully erupted permanent teeth (except third molar). 3. Age 13-20 patients. 4. No previous orthodontic treatment. 5. Good oral and general health. 6. No systemic disease or regular medication that could interfere with and/or affect orthodontic teeth movement. Exclusion criteria: 1. Patients with impacted canines. 2. Patients with severe crowding. 3. Patients with untreated decay or any endodontic lesions. 4. Patients with thyroid, parathyroid, or renal and liver disease.
Where this trial is running
Cairo, Cairo Governorate
- Orthodontic Outpatient Clinic, Faculty of Dental Medicine, Al-Azhar University — Cairo, Cairo Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: Mahmoud Elsaid Elsayed E Mahmoud Elsaid, BDS
- Email: mahmoud_elsaid@azhar.edu.eg
- Phone: +201003221008
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.