Local injection of 5-fluorouracil for treating chalazia
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
This study is testing if local injections of a drug called 5-fluorouracil can help people with chalazia better than other standard treatments like steroid shots or surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Washington Academic / other |
| Locations | 1 site (Seattle, Washington) |
| Trial ID | NCT02025023 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of local injections of 5-fluorouracil compared to other standard treatments for chalazia, including triamcinolone injections and surgical incision and curettage. It is a prospective randomized interventional study that aims to determine which treatment provides the best outcomes in terms of size reduction, pain relief, and resolution of the condition. Participants will receive one of the four treatment options, and their progress will be monitored to assess effectiveness and complications.
Who should consider this trial
Good fit: Ideal candidates are individuals with single or multiple chalazia on a single eyelid that have been present for at least one month.
Not a fit: Patients with chalazia present for less than one month or those who have previously undergone injection or incision and curettage may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could offer a less invasive and effective option for patients suffering from chalazia.
How similar studies have performed: Other studies have shown success with similar injection approaches for treating chalazia, indicating a promising avenue for this treatment.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single or multiple chalazia in a single eyelid Exclusion Criteria: * Chalazia present for less than one month and no previous injection or incision and curettage
Where this trial is running
Seattle, Washington
- University of Washington Eye Institute at Harborview — Seattle, Washington, United States (Recruiting)
Study contacts
- Principal investigator: Matthew M Zhang, MD — University of Washington Eye Institute
- Study coordinator: Simona Vuletic
- Email: simona@uw.edu
- Phone: 206-520-9728
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.