Local botulinum toxin‑A injections for children with dysfunctional voiding or persistent bedwetting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol delivers botulinum toxin‑A injections to the lower urinary tract of children with dysfunctional voiding or refractory monosymptomatic nocturnal enuresis who have not responded to conventional therapy. The procedure is performed under anesthesia and excludes children with bleeding disorders, neuromuscular disease, active urinary infection, or those unfit for anesthesia. Botulinum toxin‑A acts by inhibiting neurotransmitter release and modulating sensory receptors in the bladder and urethral sphincter to reduce involuntary contractions and improve emptying. The trial is conducted at Tanta University in Tanta, El‑Gharbia, Egypt.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children \< 18 years.
* Both sexes.
* Patients with refractory nocturnal enuresis or dysfunctional voiding who are not responding to the traditional treatment.

Exclusion Criteria:

* Bleeding disorders.
* Neuromusclar disorder(e.g.,Myasthenia gravis).
* Patients who are not fit for anaesthesia.
* Active urinary tract infection (UTI).

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Ahmad M Shalaby, MBBCH
• Email: Ahmed.m.shalaby97@gmail.com
• Phone: 00201021847979

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.