Liquid vitamin C and glutathione sachets for skin health

Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet

This test tries whether daily liquid vitamin C plus glutathione sachets improve skin appearance and reduce oxidative stress in healthy adults aged 18–65.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: TCI Co., Ltd. (Industry-sponsored)
• Locations: 1 site (Pingtung City)
• Trial ID: NCT07379216 on ClinicalTrials.gov

What this trial studies

This is a single-center, double-blinded, placebo-controlled, parallel trial of daily liquid vitamin C and glutathione sachets taken for 12 consecutive weeks. Healthy adults aged 18–65 will be randomized to active or placebo and asked to avoid other skin-active products during the study. Skin measurements and self-assessment questionnaires will be collected at baseline and at 4, 8, and 12 weeks, with fasting blood samples at baseline and week 12 to measure antioxidant markers. The trial aims to link objective skin measurements and blood antioxidant changes to supplementation over a three-month period.

Who should consider this trial

Good fit: Healthy adults 18–65 without dermatologic or systemic disorders, able to avoid other comparable products and attend study visits, are the intended participants.

Not a fit: Individuals with obvious skin surface damage, recent facial laser/peeling, current skin-affecting medications, known allergies to the ingredients, or who are pregnant or breastfeeding are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, the supplements could modestly improve skin condition and lower markers of oxidative stress over a 12-week period.

How similar studies have performed: Prior small trials and observational studies have reported antioxidant and cosmetic skin effects from vitamin C or glutathione, but high-quality randomized data remain limited.

Eligibility criteria

Inclusion Criteria:

* Healthy male or female adults, aged 18-65 years old;
* Commitment not to use products having activity comparable with that of the product to be tested during the study period;
* Free of any dermatological or systemic disorder that would interfere with results.

Exclusion Criteria:

* Subject with obvious skin surface damage;
* Subject who had oral or topical medication which may affect skin condition within 1 month;
* Individuals with known allergies to cosmetics, medications, or foods (especially those allergic to legumes/soy);
* Pregnant or breastfeeding individuals;
* Received facial laser therapy, chemical peeling in the past 2 months.
* Individuals unwilling to allow publication or public disclosure of photographs taken as part of the study results

Where this trial is running

Pingtung City

• Chia Nan University of Pharmacy & Science — Pingtung City, Taiwan (Recruiting)

Study contacts

• Principal investigator: Chia-Hua Liang, Ph.D. — Chia Nan University of Pharmacy ＆ Science
• Study coordinator: Chia-Hua Liang, Ph.D.

Conditions Skin Condition; Anti-Oxidative Stress; Vitamin C supplement; Glutathione supplement