Liquid biopsies to classify lung graft damage (LEONARDO)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-centre prospective observational cohort of lung transplant recipients followed at Sahlgrenska University Hospital. Blood will be drawn at fixed follow-up visits and at clinical events, and an in-house PCR-based cell-free DNA (cfDNA) assay will be combined with specific additional biomarkers to identify the type of allograft damage. Every sampling will be paired with the current clinical gold-standard diagnostics, and all biomarker analyses will be performed blinded at a separate laboratory. Control samples will consist of time points without detected allograft damage.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Luing Transplanted and followed up within the reach of the study paricipating centres.

A good understanding to read and write within the languages in which the consent is provided.

Exclusion Criteria:

* Not Lung Transplanted or not followed up within the reach of the study paricipating centres.

No good understanding to read and write within the languages in which the consent is provided.

Where it's running

• Sahlgrenska University hospital
  Gothenburg, Västra Götaland County, Sweden Recruiting

Study contacts

• Study coordinator: Jesper M Magnusson, MD, PhD
• Email: jesper.magnusson@gu.se
• Phone: +0463421000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.