Liposomal bupivacaine plus bupivacaine versus ropivacaine for PENG block in hip replacement
Official title: Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for PENG Block on Post Operative Pain Management in Patients Undergoing Hip Arthroplasty: a Prospective, Randomized, Single Blind, Active Controlled Study
Run by Huazhong University of Science and Technology · NCT06565910 · Data updated 2026-11-12
This trial will test whether adding liposomal bupivacaine to regular bupivacaine for a pericapsular nerve group (PENG) block gives longer and better pain relief than ropivacaine after hip replacement surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Huazhong University of Science and Technology Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | December 4, 2024 |
| Main results expected | June 1, 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | March 13, 2026 |
| Trial ID | NCT06565910 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults having hip arthroplasty for hip fracture who are ASA physical status I–II, have normal coagulation, and have no allergy to amide local anesthetics are the intended participants.
✕Probably not a fit
Patients with severe systemic disease (ASA III or higher), abnormal coagulation, or an allergy to amide local anesthetics would not be eligible and are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, phase 4 interventional trial enrolling patients undergoing hip arthroplasty for hip fracture who meet ASA I–II and normal coagulation criteria. Participants receive a PENG block and are assigned to receive either liposomal bupivacaine plus standard bupivacaine or ropivacaine. The study compares pain relief duration, overall analgesic efficacy, opioid consumption, patient satisfaction, and records adverse events to assess safety. Outcomes are measured in the immediate postoperative period and during standard postoperative follow-up.
Why it matters
Potential benefit: If successful, this approach could provide longer-lasting pain relief after hip replacement and reduce the need for opioid medications.
How similar studies have gone: Liposomal bupivacaine has produced longer analgesia in some wound infiltration and peripheral block studies, but results are mixed and specific evidence for PENG block remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists(ASA) I\~II * Normal coagulation * Clinical diagnosis of hip fracture Exclusion Criteria: * Presence of severe systemic diseases or ASA grade III or higher * Allergy to amide local anesthetics
Where it's running
-
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, HUST
Wuhan, Hubei, China Recruiting
Study contacts
- Study coordinator: Xijian KE, MD
- Email: kexijian@hust.edu.cn
- Phone: 13429826148
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Collarless Actis hip stem for cementless hip replacement in Asian patients
This study tests how well a collarless Actis hip stem works in adults undergoing primary hip replacement, focusing on outcomes over five years in an East Asian population.
-
Comparing implants to keep femoral neck fractures steady in adults under 65
We will test whether a new angle-stable implant (Dynaloc) keeps femoral neck fractures steadier than cancellous screws or a sliding hip screw in adults aged 18–64.
-
Improving Pre-Anesthesia Care Discussions for Hip Fracture Surgery
This study is testing a new way to help doctors and patients talk about anesthesia choices for hip fracture surgery to see if it improves decision-making and communication.
-
Comparing internal fixation and hip arthroplasty for hip fractures in elderly patients
This study is testing whether surgery to fix a hip fracture or replacing the hip altogether helps older patients feel less pain and move better after their injury.
-
Evaluating long-term outcomes of hip hemiarthroplasty surgeries
This study is trying to see how well hip hemiarthroplasty surgeries using specific implants work and are safe for adults over a long period of up to 10 years.
-
Bone marrow injection at the femoral neck fracture site in young adults with intracapsular hip fractures
This study tests whether injecting the patient’s own bone marrow into a femoral neck fracture helps it heal faster and reduces avascular necrosis in adults aged 18–55 with certain fracture types.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.