Clinical trial Recruiting at 1 site Interventional Ages 18 to 60

Lip product with Caulerpa lentillifera extract to reduce dark lips

Official title: The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation

Run by Chulalongkorn University · NCT07067879 · Data updated 2026-11-12

We will test if a lip product containing Caulerpa lentillifera extract can reduce darkened lips in Thai adults aged 18–60 who are concerned about lip pigmentation.

More Hyperpigmentation trials

Quick facts

Study typeInterventional
Ages18 Years to 60 Years
SexAll
Enrollment30 (estimated)
SponsorChulalongkorn University
Academic / other
Locations1 site (Bangkok)
StatusRecruiting
StartedJuly 23, 2025
Main results expectedAugust 13, 2025
Study endsAugust 13, 2025
Registry record updatedJuly 16, 2025
Trial IDNCT07067879 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Thai adults aged 18–60 who are bothered by darkened lips, can refrain from other lip products for seven days, have no lip abnormalities, and have no known allergy to Caulerpa lentillifera or recent medication use.

Probably not a fit

People with lip malformations, active inflammation or sores, known allergy to Caulerpa lentillifera, or who have taken medications within the prior month are unlikely to benefit from this product.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with self-reported darkened lips will apply the investigational lip product twice daily for seven days and avoid other lip products during the study. Researchers will compare objective baseline measurements (such as imaging) and participant perceptions before and after the 7-day treatment period. The study is conducted at the Faculty of Dentistry, Chulalongkorn University, with screening to exclude lip abnormalities, recent medication use, or known allergies to the product. Outcomes focus on changes in appearance and subjective perception of lip hyperpigmentation.

Why it matters

Potential benefit: If successful, the product could provide a simple, noninvasive cosmetic option to reduce lip hyperpigmentation.

How similar studies have gone: While topical natural extracts have shown limited promise for skin pigmentation generally, using Caulerpa lentillifera specifically for lip hyperpigmentation is relatively novel and has limited prior clinical data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Understand the study protocol and provide informed consent after being informed of potential risks and benefits.
* Refrain from using any other lip products, including lipstick, lip gloss, or lip conditioners, during the study period.

Exclusion Criteria:

* Have a known allergy or sensitivity to cosmetic products or Caulerpa lentillifera.
* Are on medication one month prior to study commencement.
* Exhibit lip abnormalities such as malformation, inflammation, swelling, or sores.

Where it's running

  • Faculty of dentistry, Chulalongkorn university
    Bangkok, Thailand
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.