Linperlisib with immunochemotherapy for relapsed large B-cell lymphoma

An Open-label, Multicenter, Multi-cohort Clinical Study of Linperlisib Combined With Standard Immunochemotherapy in the Treatment of Relapsed/Refractory Large B-Cell Lymphoma Failing to First-line Therapy

This study is testing if adding Linperlisib to standard immunochemotherapy helps people with relapsed large B-cell lymphoma feel better and have more treatment options.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 89 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Institute of Hematology & Blood Diseases Hospital, China (Academic / other)
• Drugs / interventions: chemotherapy, radiation, prednisone
• Locations: 1 site (Tianjin, Tianjin Municipality)
• Trial ID: NCT06489808 on ClinicalTrials.gov

What this trial studies

This phase 2, open-label, multicenter study evaluates the efficacy and safety of Linperlisib combined with standard immunochemotherapy in patients with relapsed or refractory large B-cell lymphoma (LBCL) after first-line treatment. The study includes a safety run-in phase to determine the recommended dose based on dose-limiting toxicities, followed by a dose expansion phase with two cohorts. Cohort 1 involves transplant-ineligible patients receiving Linperlisib with R-Gemox, while Cohort 2 includes patients scheduled for transplantation receiving Linperlisib with various regimens before autologous stem cell transplantation.

Who should consider this trial

Good fit: Ideal candidates are patients with histologically confirmed relapsed or refractory large B-cell lymphoma after first-line immunochemotherapy.

Not a fit: Patients who have not received prior immunochemotherapy or those with indolent lymphoma may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for patients with relapsed or refractory LBCL.

How similar studies have performed: Other studies have shown promising results with similar combinations of targeted therapies and immunochemotherapy in treating LBCL.

Eligibility criteria

Inclusion Criteria:

1. Histologically confirmed large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma unspecified (DLBCL, NOS), follicular lymphoma grade 3B (FL, 3B), high-grade B-cell lymphoma unspecified (HGBCL, NOS), DLBCL/HGBCL with MYC and BCL2 rearrangements, FL transformed DLBCL without a previous history of indolent lymphoma.
2. Relapsed or refractory after first-line immunochemotherapy (which must include CD20 monoclonal antibody and anthracycline) 1)Refractory is defined as failure to achieve a complete response to first-line therapy (excluding patients who are intolerant to first-line therapy), including progressive disease (PD) as the best response to first-line therapy; stable disease (SD) as the best response after at least 4 cycles of first-line therapy (eg, 4 cycles of R-CHOP); partial response (PR) as the best response after at least 6 cycles of first-line therapy with biopsy-confirmed residual disease or disease progression within 12 months of initiating first-line therapy; complete response to first-line therapy followed by progression within 12 months after the end of therapy. 2)Relapse was defined as a complete response to first-line therapy followed by progression confirmed more than 12 months after the end of therapy.
3. Subjects must have at least 1 measurable lesion/evaluable lesion that meets the 2014 version of the Lugano Lymphoma Evaluation Criteria.
4. Subjects has no known or suspected central nervous system involvement by lymphoma.
5. Previous treatment with any antineoplastic therapy (including radiation therapy, chemotherapy, hormonal therapy, surgery, or molecular targeted therapy) for which participation in this trial must have exceeded 2 weeks or 5 drug half-lives, whichever is shorter.
6. Age ≥ 18 years.
7. ECOG score 0-2.
8. Expected survival ≥ 3 months.
9. Women of Childbearing Potential subjects must have a negative serum/urine pregnancy test within 7 days prior to the first dose; female subjects of childbearing potential and male subjects with partners of childbearing potential, as well as their partners, should agree to use effective contraception from signing the ICF until 6 months after the last dose of study drug.
10. Able to comply with the trial protocol as judged by the investigator.
11. Each subject (or legally acceptable representative) voluntarily joined the study and signed an informed consent form.

    \-

Exclusion Criteria:

1. Other malignancies within the last 5 years, except radically treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, carcinoma in situ of the breast, and carcinoma in situ of the cervix.
2. Previous autologous or allogeneic hematopoietic stem cell transplantation.
3. History of Richter transformation.
4. Received \> 1 line of systemic antineoplastic therapy.
5. Prior treatment with PI3K inhibitors.
6. Known hypersensitivity to trial products.
7. Active viral, bacterial, or fungal infection requiring treatment (eg, pneumonia, etc.).
8. Requiring prolonged systemic hormones (at doses equivalent to \> 10 mg prednisone/day) or any other form of immunosuppressive therapy. Subjects taking inhaled or topical corticosteroids may be enrolled.
9. Concomitant diseases and medical history:

   1. Multiple factors affecting oral medication (e.g. inability to swallow, chronic diarrhea, ileus, etc.).
   2. Patients with a history of psychotropic substance abuse who cannot quit or have mental disorders.
   3. Subjects with any severe and/or uncontrolled disease including:

      1)Unsatisfactory blood pressure control (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 100 mmHg). 2)Patients with ≥ grade 2 myocardial ischemia or myocardial infarction, arrhythmia (including QTc ≥ 450 ms (male), QTc ≥ 470 ms (female)) and ≥ grade 2 congestive heart failure (New York Heart Association (NYHA) classification). 3)Active interstitial pneumonia or other chronic lung disease resulting in severely impaired lung function defined as FEV1 and DLCOc \< 60% of predicted normal; history of interstitial pneumonia due to COVID-19. 4)Abnormal liver: I.Decompensated cirrhosis (Child-Pugh class B or C). II.Known history of clinically significant liver disease. 5)Renal failure requiring hemodialysis or peritoneal dialysis. 6)Subjects with uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage. 7)Urine routine showed urine protein ≥ + +, and confirmed 24-hour urine protein quantification \> 1.0 g.
   4. Patients with active or history of autoimmune diseases that may relapse (e.g., systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, autoimmune thyroid disease, multiple sclerosis, vasculitis, glomerulonephritis, etc.), or patients at high risk. Patients with autoimmune hypothyroidism requiring only hormone replacement therapy may be considered for enrollment if the disease is stable as assessed by the investigator.
10. Known history of human immunodeficiency virus (HIV) infection and/or acquired immunodeficiency syndrome.
11. Positive pregnancy test at baseline in female patients who are pregnant, lactating, or of childbearing potential.
12. Concurrent medical conditions that, in the investigator 's judgment, would seriously compromise the patient' s safety or the patient 's completion of the study.

    \-

Where this trial is running

Tianjin, Tianjin Municipality

• Institute of Hematology & Blood Disease Hospital — Tianjin, Tianjin Municipality, China (Recruiting)

Study contacts

• Principal investigator: Lugui Qiu — Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC
• Study coordinator: Wei Liu, MD

Conditions Relapsed/Refractory Large B-Cell Lymphoma; Linperlisib; Immunochemotherapy