Linking blood inflammation markers and chest CT findings in adults with stable bronchiectasis who frequently flare
Correlation of Inflammatory Markers and Radiological Findings in Stable Bronchiectasis Patients With Exacerbation Phenotype
Sohag University · NCT07495982
This project will test whether blood inflammatory markers match chest CT findings in adults with stable non-CF bronchiectasis who have frequent exacerbations.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sohag University (other) |
| Locations | 1 site (Sohag) |
| Trial ID | NCT07495982 on ClinicalTrials.gov |
What this trial studies
This observational project will enroll adults (≥18) with non-cystic fibrosis bronchiectasis confirmed by high-resolution CT and characterize their exacerbation phenotype. Participants who are clinically stable will have blood inflammatory markers measured and their recent HRCT scans reviewed. Investigators will look for correlations between biomarker levels, specific radiological features, and the history of frequent exacerbations (≥2 per year). All activities are observational and conducted without experimental treatments at the Faculty of Medicine, Sohag University.
Who should consider this trial
Good fit: Adults (≥18) with HRCT-confirmed non-cystic fibrosis bronchiectasis, particularly those with a history of two or more exacerbations per year and who are clinically stable at sampling, are ideal candidates.
Not a fit: People with cystic fibrosis-related bronchiectasis, active pulmonary tuberculosis, advanced hepatic or renal failure, current immunosuppressive therapy, or those unwilling to participate are excluded and unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, the findings could help identify simple blood markers that signal higher risk of exacerbations and guide closer monitoring or more personalized care.
How similar studies have performed: Previous observational studies have reported some links between inflammatory markers and imaging severity in bronchiectasis, but results have been inconsistent and this approach is not yet validated for routine care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients (≥18 years) with non-cystic fibrosis bronchiectasis confirmed by High Resolution Computed Tomography (HRCT). Exclusion Criteria: * Patients with cystic fibrosis-related bronchiectasis. * Patients with active pulmonary tuberculosis. * Patients with chronic debilitating diseases e.g. advanced hepatic or renal diseases. * Patients with primary autoimmune or malignancy requiring immunosuppressive therapy at the time of the marker measurement. * Patients refusing participation.
Where this trial is running
Sohag
- Faculty of medicine — Sohag, Egypt (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Correlation of Inflammatory Markers and Radiological Findings in Stable Bronchiectasis Patients