Link between liver function and sepsis severity

Elevated Initial APRI Value Was Associated With the Development of Sepsis-associated Liver Dysfunction in Adult Patients With Sepsis

This study looks at how liver function affects the severity of sepsis and survival rates in adults admitted to the ICU for sepsis.

Quick facts

• Study type: Observational
• Enrollment: 160 (estimated)
• Ages: 18 Years to 90 Years
• Sex: All
• Sponsor: Chinese Medical Association (Research network)
• Locations: 1 site (Nanjing, Jiangsu)
• Trial ID: NCT05999331 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between elevated initial aspartate aminotransferase to platelet ratio index (APRI) values and sepsis-associated liver dysfunction (SALD) in adult patients. It focuses on patients who have been admitted to the ICU for sepsis, analyzing their liver function indicators and various clinical parameters during their first 24 hours of admission. The study aims to identify how liver dysfunction impacts the severity of sepsis and associated mortality rates. Data is extracted from the MIMIC IV database, ensuring a comprehensive analysis of relevant clinical factors.

Who should consider this trial

Good fit: Ideal candidates for this study are adult patients (≥18 years) who are admitted to the ICU with sepsis and have available data for their first hospitalization.

Not a fit: Patients with chronic liver diseases or those who have had a length of ICU stay of less than 24 hours will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the understanding of liver dysfunction in sepsis, potentially leading to better management strategies and improved patient outcomes.

How similar studies have performed: While the specific approach of using APRI in this context may be novel, similar studies have shown that liver function indicators can significantly impact outcomes in sepsis.

Eligibility criteria

Inclusion Criteria:

* adult sepsis patients (≥18 years)

Exclusion Criteria:

* all types of chronic liver disease;
* viral hepatitis;
* primary acute cholangiopathies;
* cholecystitis;
* hepatic infarction;
* liver necrosis;
* liver trauma;
* length of ICU stay \< 24 hours;
* Patients without simultaneous AST and PLT data in the first 24 hours after ICU admission.

Where this trial is running

Nanjing, Jiangsu

• Institute of General Surgery of Jinling Hospital — Nanjing, Jiangsu, China (Recruiting)

Study contacts

• Study coordinator: Beiyuan Zhang, M.S.

Conditions Liver Dysfunction; Sepsis-associated Liver Dysfunction