Home › Trials › NCT06286345
Clinical trial No longer in our active list Interventional Ages 18 and up

Lifestyle intervention for patients with depression in general practice

Official title: Lifestyle InterVEntion Study in General Practice: LIVES - GP

Run by University Medical Center Groningen · NCT06286345 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing a new lifestyle program designed to help people with depression improve their mental health and overall well-being in a regular doctor's office.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorUniversity Medical Center Groningen
Academic / other
Locations1 site (Groningen)
Trial IDNCT06286345 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults diagnosed with depressive symptoms or disorder, with a body mass index of 25 or higher.

Probably not a fit

Patients currently receiving treatment in mental health care or those with severe somatic or neurological diseases may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates the feasibility of a multimodal lifestyle intervention (MLI) tailored for patients with depression in a general practice setting. The study aims to address the unhealthy lifestyle often associated with depression, which can lead to chronic physical diseases like cardiovascular issues. By conducting an observational single-group prospective cohort study with 50 participants, the researchers will evaluate various outcome measures including mental health, lifestyle factors, and quality of life. The goal is to identify key factors that influence the successful implementation of this intervention in primary care.

Why it matters

Potential benefit: If successful, this intervention could improve the overall health and quality of life for patients suffering from depression.

How similar studies have gone: Previous studies have shown promising results for lifestyle interventions in mental health care, but this approach in a general practice setting is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Diagnosis of depressive symptoms or depressive disorder in the past year as registered in the general practice electronic health record and coded according to the International Classification of Primary Care (ICPC) as P03 and P76, respectively, or currently treated for depressive symptoms or depressive disorder in general practice.
* At least mild depressive symptom level according to the Quick Inventory Depressive Symptomatology-Self-Report (QIDS-SR) (score ≥6)
* Body mass index ≥ 25 kg/m2 or increased waist circumference (\>88 cm (women) of \>102 cm (men)).

Exclusion Criteria:

* Current treatment in mental health care (GGZ in Dutch)
* Severe somatic / neurological disease at the discretion of the GP
* Currently participating in another lifestyle intervention
* Insufficient proficiency in Dutch
* Inability to read and write

Where it's running

  • University Medical Center Groningen
    Groningen, Netherlands     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Depression, Unipolar 9Cardiovascular Diseases 365University Medical Center Groningen 94
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.