Lifestyle intervention for patients with depression in general practice

Lifestyle InterVEntion Study in General Practice: LIVES - GP

NA · University Medical Center Groningen · NCT06286345

This study is testing a new lifestyle program designed to help people with depression improve their mental health and overall well-being in a regular doctor's office.

Quick facts

PhaseNA
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity Medical Center Groningen (other)
Locations1 site (Groningen)
Trial IDNCT06286345 on ClinicalTrials.gov

What this trial studies

This research investigates the feasibility of a multimodal lifestyle intervention (MLI) tailored for patients with depression in a general practice setting. The study aims to address the unhealthy lifestyle often associated with depression, which can lead to chronic physical diseases like cardiovascular issues. By conducting an observational single-group prospective cohort study with 50 participants, the researchers will evaluate various outcome measures including mental health, lifestyle factors, and quality of life. The goal is to identify key factors that influence the successful implementation of this intervention in primary care.

Who should consider this trial

Good fit: Ideal candidates are adults diagnosed with depressive symptoms or disorder, with a body mass index of 25 or higher.

Not a fit: Patients currently receiving treatment in mental health care or those with severe somatic or neurological diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could improve the overall health and quality of life for patients suffering from depression.

How similar studies have performed: Previous studies have shown promising results for lifestyle interventions in mental health care, but this approach in a general practice setting is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of depressive symptoms or depressive disorder in the past year as registered in the general practice electronic health record and coded according to the International Classification of Primary Care (ICPC) as P03 and P76, respectively, or currently treated for depressive symptoms or depressive disorder in general practice.
* At least mild depressive symptom level according to the Quick Inventory Depressive Symptomatology-Self-Report (QIDS-SR) (score ≥6)
* Body mass index ≥ 25 kg/m2 or increased waist circumference (\>88 cm (women) of \>102 cm (men)).

Exclusion Criteria:

* Current treatment in mental health care (GGZ in Dutch)
* Severe somatic / neurological disease at the discretion of the GP
* Currently participating in another lifestyle intervention
* Insufficient proficiency in Dutch
* Inability to read and write

Where this trial is running

Groningen

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Depression, Unipolar, Cardiovascular Diseases, depression, lifestyle, general practice

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.