Lidocaine versus ketamine infusions for pain control after thyroidectomy
Official title: Effects of Perioperative Intravenous Lidocaine Infusion Versus Ketamine Infusion For Postoperative Analgesia in Patients Undergoing Thyroidectomy : A Randomized Controlled Trial
Run by Sohag University · NCT07045870 · Data updated 2026-11-12
This will test whether lidocaine or ketamine infusions help adults aged 18–75 have less pain after thyroid surgery compared with saline.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Status | Recruiting |
| Started | June 11, 2025 |
| Main results expected | December 15, 2025 |
| Study ends | December 15, 2025 |
| Registry record updated | July 10, 2025 |
| Trial ID | NCT07045870 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 of either sex scheduled for thyroidectomy who do not have toxic goiter, hyperthyroidism, BMI over 30, uncontrolled hypertension, severe liver or kidney disease, or allergies to lidocaine or ketamine.
✕Probably not a fit
Patients with toxic goiter or hyperthyroidism, BMI >30, uncontrolled hypertension, severe liver or kidney disease, or allergy to the study drugs are excluded and would not be eligible to participate or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults 18–75 scheduled for thyroidectomy at Sohag University Hospital will be assigned to receive a perioperative infusion of lidocaine, ketamine, or saline and postoperative pain outcomes will be compared. The protocol excludes patients with toxic goiter, hyperthyroidism, BMI over 30, uncontrolled hypertension, severe liver or kidney disease, or known allergies to the study drugs. Pain scores, analgesic (including opioid) consumption, and adverse events will be recorded after surgery to measure effectiveness and safety. This single-center interventional trial aims to identify which infusion provides better pain relief and potentially reduces opioid needs after thyroidectomy.
Why it matters
Potential benefit: If successful, one of the infusions could lower postoperative pain and reduce opioid use after thyroidectomy.
How similar studies have gone: Previous studies in various surgical populations have shown that IV lidocaine and low‑dose ketamine can reduce postoperative pain and opioid requirements, but direct comparisons specifically in thyroidectomy are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age from 18 to 75 years old * both sexes * scheduled for thyroidectomy Exclusion Criteria: * toxic goiter * (BMI) exceeding 30 kg / m2 * un controlled hypertension * sever liver or kidney disorders * allergy to study drugs * hyperthyroidism
Where it's running
-
Sohag university hospital
Sohag, Egypt Recruiting
Study contacts
- Study coordinator: Mario N Ishak, Resident
- Email: marionashaat63@gmail.com
- Phone: 01210609798
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.