Lidocaine versus ketamine infusions for pain control after thyroidectomy
Effects of Perioperative Intravenous Lidocaine Infusion Versus Ketamine Infusion For Postoperative Analgesia in Patients Undergoing Thyroidectomy : A Randomized Controlled Trial
This will test whether lidocaine or ketamine infusions help adults aged 18–75 have less pain after thyroid surgery compared with saline.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Trial ID | NCT07045870 on ClinicalTrials.gov |
What this trial studies
Adults 18–75 scheduled for thyroidectomy at Sohag University Hospital will be assigned to receive a perioperative infusion of lidocaine, ketamine, or saline and postoperative pain outcomes will be compared. The protocol excludes patients with toxic goiter, hyperthyroidism, BMI over 30, uncontrolled hypertension, severe liver or kidney disease, or known allergies to the study drugs. Pain scores, analgesic (including opioid) consumption, and adverse events will be recorded after surgery to measure effectiveness and safety. This single-center interventional trial aims to identify which infusion provides better pain relief and potentially reduces opioid needs after thyroidectomy.
Who should consider this trial
Good fit: Adults aged 18–75 of either sex scheduled for thyroidectomy who do not have toxic goiter, hyperthyroidism, BMI over 30, uncontrolled hypertension, severe liver or kidney disease, or allergies to lidocaine or ketamine.
Not a fit: Patients with toxic goiter or hyperthyroidism, BMI >30, uncontrolled hypertension, severe liver or kidney disease, or allergy to the study drugs are excluded and would not be eligible to participate or benefit.
Why it matters
Potential benefit: If successful, one of the infusions could lower postoperative pain and reduce opioid use after thyroidectomy.
How similar studies have performed: Previous studies in various surgical populations have shown that IV lidocaine and low‑dose ketamine can reduce postoperative pain and opioid requirements, but direct comparisons specifically in thyroidectomy are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age from 18 to 75 years old * both sexes * scheduled for thyroidectomy Exclusion Criteria: * toxic goiter * (BMI) exceeding 30 kg / m2 * un controlled hypertension * sever liver or kidney disorders * allergy to study drugs * hyperthyroidism
Where this trial is running
Sohag
- Sohag university hospital — Sohag, Egypt (Recruiting)
Study contacts
- Study coordinator: Mario N Ishak, Resident
- Email: marionashaat63@gmail.com
- Phone: 01210609798
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.