Clinical trial Recruiting at 1 site Interventional Ages 18 to 75

Lidocaine versus ketamine infusions for pain control after thyroidectomy

Official title: Effects of Perioperative Intravenous Lidocaine Infusion Versus Ketamine Infusion For Postoperative Analgesia in Patients Undergoing Thyroidectomy : A Randomized Controlled Trial

Run by Sohag University · NCT07045870 · Data updated 2026-11-12

This will test whether lidocaine or ketamine infusions help adults aged 18–75 have less pain after thyroid surgery compared with saline.

Quick facts

Study typeInterventional
Ages18 Years to 75 Years
SexAll
Enrollment60 (estimated)
SponsorSohag University
Academic / other
Locations1 site (Sohag)
StatusRecruiting
StartedJune 11, 2025
Main results expectedDecember 15, 2025
Study endsDecember 15, 2025
Registry record updatedJuly 10, 2025
Trial IDNCT07045870 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–75 of either sex scheduled for thyroidectomy who do not have toxic goiter, hyperthyroidism, BMI over 30, uncontrolled hypertension, severe liver or kidney disease, or allergies to lidocaine or ketamine.

Probably not a fit

Patients with toxic goiter or hyperthyroidism, BMI >30, uncontrolled hypertension, severe liver or kidney disease, or allergy to the study drugs are excluded and would not be eligible to participate or benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults 18–75 scheduled for thyroidectomy at Sohag University Hospital will be assigned to receive a perioperative infusion of lidocaine, ketamine, or saline and postoperative pain outcomes will be compared. The protocol excludes patients with toxic goiter, hyperthyroidism, BMI over 30, uncontrolled hypertension, severe liver or kidney disease, or known allergies to the study drugs. Pain scores, analgesic (including opioid) consumption, and adverse events will be recorded after surgery to measure effectiveness and safety. This single-center interventional trial aims to identify which infusion provides better pain relief and potentially reduces opioid needs after thyroidectomy.

Why it matters

Potential benefit: If successful, one of the infusions could lower postoperative pain and reduce opioid use after thyroidectomy.

How similar studies have gone: Previous studies in various surgical populations have shown that IV lidocaine and low‑dose ketamine can reduce postoperative pain and opioid requirements, but direct comparisons specifically in thyroidectomy are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age from 18 to 75 years old
* both sexes
* scheduled for thyroidectomy

Exclusion Criteria:

* toxic goiter
* (BMI) exceeding 30 kg / m2
* un controlled hypertension
* sever liver or kidney disorders
* allergy to study drugs
* hyperthyroidism

Where it's running

  • Sohag university hospital
    Sohag, Egypt
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.