Lidocaine versus diphenhydramine for numbing simple skin lacerations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults presenting to the emergency department with simple skin lacerations that require a single-layer suture and are appropriate for repair by emergency physicians will be enrolled. Participants will receive local infiltration with either diphenhydramine or 1% lidocaine and pain scores for the injection and the repair procedure will be recorded. The study is designed as a noninferiority comparison to determine whether diphenhydramine provides similar anesthesia to lidocaine for bedside laceration repair. Patients with active bleeding, complex lacerations, allergies to the study drugs, or cases where epinephrine would be beneficial are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Lacerations requiring one layer of sutures
* Lacerations appropriate for repair by emergency physicians

Exclusion Criteria:

* Active bleeding from laceration
* Complex lacerations requiring multiple layers
* Lacerations to be repaired by a specialist service
* Patients with allergies to either diphenhydramine or lidocaine
* Laceration repairs would benefit from the use of epinephrine as an additive to the local anesthetic

Where it's running

• Bethesda Hospital East
  Boynton Beach, Florida, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.