Levothyroxine for heart transplant recipients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the survival benefits of levothyroxine supplementation in heart transplant recipients compared to a placebo. Conducted at the University of California, San Francisco, it is a double-blinded, placebo-controlled, randomized study. Participants will be assigned to receive either levothyroxine or normal saline, with the aim of determining if levothyroxine improves post-operative survival rates. The study is motivated by previous findings that suggest thyroid hormone may enhance organ transplant outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Participants must be listed for heart transplantation
2. Age ≥18 years
3. Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

1. Patients with pre-existing thyroid related condition including hypothyroidism, hyperthyroidism and malignancy
2. Patients with a known allergy or intolerance to levothyroxine
3. Patients participating in another study evaluating an investigational drug within the past 30 days.

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Jason Smith, MD — University of California, San Francisco
• Study coordinator: Corinne Dietz
• Email: Corinne.dietz@ucsf.edu
• Phone: 415-353-7083

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Letermovir versus valganciclovir to prevent CMV after heart transplant

  This trial will test whether letermovir or valganciclovir better prevents CMV viremia in adults at moderate-to-high CMV risk after a heart transplant.

  Recruiting at 2 sites Phase 2/3 Columbia University · New York, New York and 1 other locations · NCT07079735

• Intestinal microsporidiosis in French heart transplant recipients

  This project will collect past medical data to see how often and how severe intestinal microsporidiosis is in heart transplant patients in France.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06986980

• Evaluating infection management in children with heart-assist devices

  This study looks at how to better manage infections in children using heart-assist devices to help improve their health while they wait for a heart transplant.

  Recruiting Claude Bernard University · Lyon · NCT06464016

• Using Belatacept to Improve Kidney Function in Heart Transplant Patients

  This study is testing if a new medication called belatacept can help protect kidney function in heart transplant patients who are at risk of kidney problems.

  Recruiting at 4 sites Phase 2 Nantes University Hospital · Bordeaux and 3 other locations · NCT04180085

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.