Letrozole preparation for frozen embryo transfer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of a letrozole-induced endometrial preparation protocol compared to natural cycles and hormone replacement protocols in women undergoing frozen-thawed embryo transfer (FET) after IVF or ICSI. The study aims to evaluate pregnancy outcomes, including live birth rates and clinical pregnancy rates, as well as other important indicators such as spontaneous abortion rates and the number of clinic visits required. Participants will be randomized based on their menstrual cycle regularity and will undergo specific treatment regimens starting from the early days of their cycle.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Women \<40 years of age undergoing IVF or ICSI at our reproductive center with a total of ≤3 superovulation cycles , and with ≥2 cleavage embryos or ≥1 blastocyst were cryopreserved. Previous cycles of embryo transfer ≤ 2 and only one transfer cycle with 1-2 embryos per study subject was enrolled.

Exclusion Criteria:

1. Patients with chromosomal abnormalities in either spouse, hydrosalpinx, severe endometriosis, adenomyosis, and uterine and uterine cavity organic diseases such as uterine malformations, endometrial polyps, and uterine adhesions;
2. patients who underwent pre-implantation genetic diagnosis (PGT);
3. patients who underwent ICSI using surgically obtained epididymal or testicular spermatozoa;
4. patients with a Body mass index (BMI, = weight/height2 ) \> 30 kg/m2;
5. patients with recurrent spontaneous abortions;
6. patients with sequential embryo transfer.

Where it's running

• Yu Xiao
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Chengliang Zhou, Dr.
• Email: chengliang_zhou@163.com
• Phone: 08613758240793

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.