Leptin as a marker of chemotherapy sensitivity in adult AML

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this prospective observational study, investigators will collect bone marrow supernatant from adults with newly diagnosed non-APL AML before any chemotherapy and measure leptin levels. Leptin concentrations will be correlated with treatment responses and clinical outcomes following standard chemotherapy to test whether higher leptin predicts chemoresistance and relapse. The approach links laboratory measures of marrow adipokines to real-world patient outcomes without changing standard care. The study is single-center at Fujian Medical University Union Hospital and excludes patients with prior chemotherapy, active major infections, other untreated malignancies, severe organ dysfunction, or inability to consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Clinical diagnosis aligns with the "Chinese guidelines for diagnosis and treatment of adult acute myeloid leukemia (not APL) (2023)";
2. All patients are experiencing their first onset of the disease and have not received any related chemotherapy prior to the study;
3. Patients participate in the study accompanied by family members and sign informed consent documents.

Exclusion Criteria:

1. Patients with concurrent malignancies requiring treatment;
2. Presence of infectious diseases, including SARS, viral hepatitis, or HIV/ AIDS;
3. Major surgery performed within the last 21 days;
4. Performance Status (PS) score \>3;
5. Severe liver or kidney dysfunction or serious infection;
6. Severe psychiatric conditions that impair understanding of the study protocol or voluntary withdrawal.

Where it's running

• Fujian Medical University Union Hospital
  Fuzhou, Fujian, China Recruiting

Study contacts

• Study coordinator: Huifang Huang
• Email: huanghuif@fjmu.edu.cn
• Phone: 13365910318

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.