Lemon juice or apple cider vinegar with bread: effects on blood sugar and fullness
Official title: The Effect of Lemon Juice and Apple Cider Vinegar on Postprandial Blood Glucose and Satiety in Healthy Individuals
Run by Alanya Alaaddin Keykubat University · NCT07563985 · Data updated 2026-11-12
This test checks whether drinking lemon juice or apple cider vinegar with white bread slows the rise in blood sugar and increases feelings of fullness in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Alanya Alaaddin Keykubat University Academic / other |
| Locations | 1 site (Alanya, Antalya) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | July 1, 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | May 4, 2026 |
| Trial ID | NCT07563985 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18–35 with a BMI between 18.5 and 25 who can attend multiple morning visits and comply with fasting requirements are ideal candidates.
✕Probably not a fit
People with chronic metabolic or gastrointestinal diseases, BMI outside the 18.5–25 range, current smokers, pregnant or lactating women, or those taking medications that affect glucose are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy volunteers attend multiple morning visits and consume a fixed portion of white bread together with either water, water plus lemon juice (50 g or 100 g), or water plus apple cider vinegar (10 g or 20 g), with one-week breaks between each test. Blood glucose is measured at regular intervals for three hours after eating and participants report satiety using standardized ratings. The design compares two doses of lemon juice and two doses of vinegar against a water control to detect dose-related effects on postprandial glycemia and fullness. Recruitment targets healthy adults aged 18–35 with BMI 18.5–25 at a single center in Alanya, Turkey.
Why it matters
Potential benefit: If successful, this approach could offer a simple, widely available dietary option to blunt post-meal blood sugar spikes and help control appetite.
How similar studies have gone: Small prior studies suggest vinegar can modestly reduce postprandial glucose, while evidence for lemon juice is more limited and inconsistent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy male and female volunteers aged 18-35 years * Body Mass Index (BMI) between 18.5 and 25.0 kg/m² * Willingness to provide written informed consent * Ability to comply with study procedures and fasting requirements * No history of chronic metabolic, gastrointestinal, or endocrine diseases Exclusion Criteria: * Presence of any chronic disease (e.g., diabetes mellitus, cardiovascular disease, gastrointestinal disorders) * Food allergies or intolerances to study foods (white bread, lemon juice, apple cider vinegar) * BMI \<18.5 or \>25.0 kg/m² * Regular participation in high-intensity physical activity (≥5 days/week) * Current or recent (past 3 months) smoking or smoking cessation * Use of any medication or supplements affecting glucose metabolism * History of eating disorders * Pregnancy, lactation, or menopause * Female participants currently in menstruation period (testing will be postponed during menstruation days) * Alcohol consumption within 24 hours prior to testing days * Caffeine intake or major dietary changes on the day before testing
Where it's running
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Alanya Alaaddin Keykubat University
Alanya, Antalya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ezgi Toptaş Bıyıklı, Assistant Professor
- Email: ezgi.biyikli@alanya.edu.tr
- Phone: 90 505 751 96 21
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.