Left motor cortex rTMS effects on brain connectivity
Effects of Left Primary Motor Cortex rTMS on Cortical Connectivity Assessed With TMS-EEG Across Left M1, Right M1, Premotor, and Occipital Cortices
NA · Aalborg University · NCT07580989
This will test whether one session of rTMS to the left motor cortex changes EEG-measured brain connectivity in healthy adult volunteers.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Aalborg University (other) |
| Locations | 1 site (Gistrup) |
| Trial ID | NCT07580989 on ClinicalTrials.gov |
What this trial studies
Healthy volunteers will receive a single session of repetitive transcranial magnetic stimulation (rTMS) over the left primary motor cortex with TMS-EEG recordings taken before and after stimulation. TMS pulses will be applied to four cortical targets—the left and right primary motor cortices, left premotor cortex, and right occipital cortex—to record TMS-evoked potentials (TEPs) that reflect cortical reactivity and connectivity. Pre- versus post-rTMS comparisons of TEPs will be used to map changes in network responses and determine whether one rTMS session alters large-scale cortical interactions. Participants will be screened for safety and excluded for neurological, psychiatric, chronic pain, or substance-use contraindications.
Who should consider this trial
Good fit: Ideal participants are healthy adults who speak English, can consent and cooperate with procedures, and have no history of neurological, psychiatric, chronic pain, or contraindications to rTMS.
Not a fit: People with current or past neurological or psychiatric disorders, chronic or acute pain, substance use, or contraindications to TMS (for example epilepsy or metal in the head/jaw) are not likely to benefit and are excluded.
Why it matters
Potential benefit: If successful, the results could clarify how rTMS changes brain network activity and help refine stimulation targets or protocols for treating neurological and psychiatric conditions.
How similar studies have performed: Previous TMS-EEG and rTMS studies have demonstrated modulation of cortical responses after stimulation, but findings are variable and the mechanisms of network-level changes remain incompletely established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Healthy men and women Speak and understand English Exclusion Criteria: Drug addiction defined as the use of cannabis, opioids or other drugs Previous neurologic, musculoskeletal or mental illnesses Lack of ability to cooperate History of chronic pain or current acute pain Contraindications to rTMS application (history of epilepsy, metal in the head or jaw etc.). Failure to pass the "TASS questionnaire" (TASS = Transcranial Magnetic Stimulation Adult Safety Screen)
Where this trial is running
Gistrup
- Aalborg University — Gistrup, Denmark (RECRUITING)
Study contacts
- Study coordinator: Enrico De Martino
- Email: edm@hst.aau.dk
- Phone: +4591811183
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Repetitive Transcranial Magnetic Stimulation, Motor Cortex, Premotor Cortex, Occipital Cortex, Electroencephalography