Left motor cortex rTMS effects on brain connectivity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy volunteers will receive a single session of repetitive transcranial magnetic stimulation (rTMS) over the left primary motor cortex with TMS-EEG recordings taken before and after stimulation. TMS pulses will be applied to four cortical targets—the left and right primary motor cortices, left premotor cortex, and right occipital cortex—to record TMS-evoked potentials (TEPs) that reflect cortical reactivity and connectivity. Pre- versus post-rTMS comparisons of TEPs will be used to map changes in network responses and determine whether one rTMS session alters large-scale cortical interactions. Participants will be screened for safety and excluded for neurological, psychiatric, chronic pain, or substance-use contraindications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy men and women
* Speak and understand English

Exclusion Criteria:

* Drug addiction defined as the use of cannabis, opioids or other drugs
* Previous neurologic, musculoskeletal or mental illnesses
* Lack of ability to cooperate
* History of chronic pain or current acute pain
* Contraindications to rTMS application (history of epilepsy, metal in the head or jaw etc.).
* Failure to pass the "TASS questionnaire" (TASS = Transcranial Magnetic Stimulation Adult Safety Screen)

Where it's running

• Aalborg University
  Gistrup, Denmark Recruiting

Study contacts

• Study coordinator: Enrico De Martino
• Email: edm@hst.aau.dk
• Phone: +4591811183

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.