Laser-assisted total pulpotomy vs conventional total pulpotomy in symptomatic irreversible pulpitis
Official title: Laser-assisted Versus Conventional Total Pulpotomy for Postoperative Pain and Clinical-Radiographic Outcomes in Mature Molars With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial
Run by Kutahya Health Sciences University · NCT07850258 · Data updated 2026-11-12
A randomized trial tests whether using an Er:YAG laser to stop bleeding during total pulpotomy in permanent molars with symptomatic irreversible pulpitis provides different pain and healing outcomes compared with the conventional sodium hypochlorite method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years to 40 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Kutahya Health Sciences University Academic / other |
| Locations | 1 site (Kütahya, Merkez) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | July 1, 2026 |
| Study ends | July 1, 2027 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07850258 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 12–40 years old, systemically healthy (ASA I–II), with permanent molars diagnosed with symptomatic irreversible pulpitis and suitable for rubber dam isolation.
✕Probably not a fit
Patients with pulp necrosis, sinus tract, swelling, significant periodontal disease, or inability to achieve hemostasis or isolation may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, controlled trial compares two approaches to vital pulp therapy in permanent molars diagnosed with symptomatic irreversible pulpitis. Participants aged 12 to 40 are randomly assigned to either laser-assisted hemostasis or conventional chemical hemostasis during total pulpotomy, with Biodentine placed over remaining pulp tissue and a standard restoration applied. Postoperative pain is tracked at multiple early timepoints, and clinical and radiographic outcomes are monitored to determine treatment success. The study aims to see if laser assistance yields lower pain and better tissue outcomes than the conventional approach.
Why it matters
Potential benefit: If successful, the laser-assisted method could reduce postoperative pain and improve clinical and radiographic healing in vital pulp therapy.
How similar studies have gone: Prior studies in vital pulp therapy have shown feasibility of laser-assisted hemostasis, but results for pain and radiographic outcomes vary and this direct comparison is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants aged 12-40 years * Systemically healthy individuals classified as ASA I or ASA II * Permanent molar teeth * Teeth suitable for rubber dam isolation * Diagnosis of symptomatic irreversible pulpitis * Presence of spontaneous pain and/or prolonged response to thermal stimuli * Pain persisting for more than 10 seconds after cold testing * Positive pulp sensibility, supported by electric pulp testing * Normal or minimally altered periapical status with a Periapical Index (PAI) score ≤2 * Final diagnosis confirmed based on combined clinical and radiographic findings Exclusion Criteria: * Presence of sinus tract, abscess, or swelling * Internal or external root resorption * Pathological tooth mobility * Periodontally compromised teeth, including probing depth ≥4 mm and/or -clinical attachment loss * Pulp necrosis or negative pulp sensibility tests * Absence of bleeding after pulp exposure * More than one carious tooth in the same region * Anterior or premolar teeth * Antibiotic use within the previous 1 week * Immunosuppressed patients * Patients unable to provide consent * Patients younger than 12 years
Where it's running
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Kutahya health sciences university faculty of dentistry
Kütahya, Merkez, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: melikşah gündüz, assistant prof.
- Email: meliksah.gunduz@ksbu.edu.tr
- Phone: +905326389337
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.