Laparoscopic versus open kidney removal: comparing outcomes and costs
Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis
This trial will test whether laparoscopic (keyhole) kidney removal or open surgery gives better outcomes and lower costs for people needing a nephrectomy for a nonfunctioning kidney or localized kidney cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 1 Year and up |
| Sex | All |
| Sponsor | Menoufia University Academic / other |
| Locations | 1 site (Shibīn al Kawm, Shebin Elkom) |
| Trial ID | NCT07461090 on ClinicalTrials.gov |
What this trial studies
This interventional comparison enrolls patients who require simple, partial (≤7 cm), or radical nephrectomy and assigns them to either laparoscopic or open surgical approaches. Key outcomes measured include operative time, blood loss, length of hospital stay, complications, and a detailed cost analysis. Eligible patients are adults fit for general anesthesia (ASA 1–3) without metastatic disease or emergency indications, and those with prior extensive ipsilateral retroperitoneal surgery are excluded. The procedures and follow-up are conducted at Menoufia Faculty of Medicine, with results intended to reflect clinical and economic performance in that setting.
Who should consider this trial
Good fit: Adults who are fit for general anesthesia (ASA 1–3) and need a simple, partial (≤7 cm, nephron-sparing) or radical nephrectomy for a nonfunctioning kidney or localized renal tumor are ideal candidates.
Not a fit: Patients with metastatic disease, emergency surgery needs, dialysis dependence, extensive prior ipsilateral surgery, planned hybrid/major concomitant procedures, or tumors with major vascular invasion are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If laparoscopic removal proves superior in this setting, patients could experience shorter hospital stays, less blood loss, fewer complications, and lower overall costs.
How similar studies have performed: Laparoscopic nephrectomy is an established technique with many studies showing reduced blood loss and faster recovery and equivalent oncologic outcomes for selected patients, though cost benefits vary by healthcare setting.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiology score 1-3. * Indication for : * Simple total nephrectomy or hemi nephrectomy: benign chronic inflammatory non-functioning kidney * Partial nephrectomy: localized renal mass ≤7 cm suitable for nephron-sparing surgery. * Radical nephrectomy or Radical nephrouretrectomy with bladder cuff: localized renal tumor requiring complete nephrectomy without major vascular invasion. * Patient deemed fit for general anesthesia and surgery. * Patient provides written informed consent. Exclusion Criteria: * emergency surgery, dialysis-dependent patients, planned hybrid procedures. * Patients with incomplete data * Patients with metastatic disease at presentation. * Prior extensive ipsilateral retroperitoneal surgery or severe adhesions precluding Laparoscopy. * Need for concomitant major procedures (eg, large bowel resection) at index operation. * Locally advanced tumor with obvious major vascular involvement requiring complex vascular reconstruction. * Uncorrected coagulopathy. * Pregnancy or Obese patient (BMI \> 40) * Inability to provide informed consent or comply with follow-up.
Where this trial is running
Shibīn al Kawm, Shebin Elkom
- Menoufia Faculty of Medicine — Shibīn al Kawm, Shebin Elkom, Egypt (Recruiting)
Study contacts
- Study coordinator: Haitham Badr Elnaggar
- Email: naggarheso@gmail.com
- Phone: 01003247485
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.