Laparoscopic removal of splenic artery aneurysm with spleen preservation
Official title: Clinical Study on Laparoscopic Resection of Splenic Artery Aneurysm With Preservation of Spleen
Run by Northern Jiangsu People's Hospital · NCT07053605 · Data updated 2026-11-12
This study tries a minimally invasive laparoscopic operation that removes splenic artery aneurysms while saving the spleen in patients with aneurysms that are large, ruptured, or growing quickly, and checks immune function and nearby blood flow over a year.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Northern Jiangsu People's Hospital Academic / other |
| Locations | 1 site (Yangzhou, Jiangsu) |
| Status | Recruiting |
| Started | June 23, 2025 |
| Main results expected | June 30, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | July 8, 2025 |
| Trial ID | NCT07053605 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a splenic artery aneurysm located on the main trunk that is >2 cm, ruptured, or growing >0.5 cm per year who can consent and undergo laparoscopic surgery are the intended participants.
✕Probably not a fit
People with active malignancy, cirrhosis with portal hypertension, recent peptic ulcer disease, recent hemorrhagic stroke, pregnancy, serious hematologic disorders, uncontrolled hypertension, or HIV are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients meeting inclusion criteria undergo preoperative evaluation and standardized laparoscopic resection of the splenic artery aneurysm performed by a single surgical team, with the spleen preserved. The same nursing team provides standardized postoperative care and a defined treatment protocol including medications and any additional therapies. Blood tests, liver and coagulation panels, immune function markers, and Doppler hemodynamics of the splenic vein, proper hepatic artery, and portal vein are measured before surgery and at 7 days, 1 month, 3 months, 6 months, and 12 months after surgery. Outcomes focus on changes in immune parameters and regional hemodynamics and their relationship to clinical recovery.
Why it matters
Potential benefit: If successful, the procedure could lower rupture risk while preserving spleen function and minimizing adverse changes in immune markers and portal/hepatic/splenic blood flow.
How similar studies have gone: Case series and reports of both laparoscopic and endovascular treatment of splenic artery aneurysms have shown favorable short-term outcomes, but there is limited high-quality comparative evidence on long-term immune and hemodynamic effects.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Asymptomatic splenic artery aneurysms with a diameter\>2 cm,ruptured splenic artery aneurysms,and splenic artery aneurysms with a diameter increase\>0.5 cm/year. Aneurysm located in the main trunk of the splenic artery. Informed consent to participate in the study. Exclusion Criteria: * Patients with malignancies Hepatic cirrhosis with portal hypertension peptic ulcer disease Recent peptic ulcer disease History of Hemorrhagic stroke Pregnancy hematological diseases Uncontrolled Hypertension Human immunodeficiency virus (HIV) infection
Where it's running
-
Clinical Medical College, Yangzhou University
Yangzhou, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Guo-Qing Jiang
- Email: jgqing2003@hotmail.com
- Phone: +8651487373382
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.