Labial bone preservation after immediate implant placement using two xenografts in the esthetic zone
Official title: Assessment of Labial Plate Thickness After Immediate Implant Placement in Type II Extraction Sockets Using Two Different Xenografts in the Esthetic Zone: a Randomized Controlled Clinical Trial
Run by Alexandria University · NCT07449806 · Data updated 2026-11-12
This trial will see if two different xenograft materials help preserve the labial bone plate when placing immediate implants in Type II extraction sockets in the upper front jaw.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 26 (estimated) |
| Sponsor | Alexandria University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Alexandria) |
| Status | Recruiting |
| Started | September 5, 2025 |
| Main results expected | May 5, 2026 |
| Study ends | September 25, 2026 |
| Registry record updated | March 6, 2026 |
| Trial ID | NCT07449806 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults needing extraction and immediate implant placement in a Type II maxillary anterior socket with at least 3 mm of apical and palatal bone, good primary stability (≥30 Ncm), and good overall health and oral hygiene.
✕Probably not a fit
Patients with current acute periapical infection, heavy smokers, medically compromised individuals, pregnant women, or those with poor oral hygiene are unlikely to benefit or may be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, parallel-group trial compares two xenograft materials (Medpark S1 and Bio-Oss) used to graft defects during immediate implant placement in Type II extraction sockets in the esthetic (maxillary anterior) zone. All participants receive immediate implant placement plus a de-epithelialized free gingival graft, then are randomized to one of the two graft materials. Clinical examinations and standardized CBCT imaging are performed at baseline and scheduled follow-up visits to measure changes in labial plate thickness, peri-implant bone stability, and implant success. Outcomes will be compared between groups to determine which material better preserves peri-implant hard tissue contours over the follow-up period.
Why it matters
Potential benefit: If successful, this could help clinicians choose the graft that better preserves front jaw bone and soft tissues, improving esthetic outcomes and long-term implant stability.
How similar studies have gone: Previous work shows xenografts like Bio-Oss can help preserve peri-implant bone in immediate implant cases, but direct randomized comparisons between different xenograft products are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with one or more non-restorable teeth or remaining roots without signs of acute infection in the maxillary anterior region. * Type II extraction sockets. * Sufficient bone (\>3 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥ 30 N cm). * Good compliance. Exclusion Criteria: * Teeth with current acute periapical infection. * Medically compromised patients. * Heavy smokers (smoking of more than 10 cigarettes per day ). * Alcohol or drug abuse. * Patients undergoing chemotherapy and radiotherapy. * Poor oral hygiene. * Vulnerable groups (pregnant females and decision- impaired individual).
Where it's running
-
Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt Recruiting
Study contacts
- Study coordinator: Basma Gamal, BDS
- Email: basmagamal816@gmail.com
- Phone: +20 10 10231477
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.