KRAS G12C pancreatic cancer: a single-arm study of HRS-7058

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, open-label, phase II study evaluating the safety and preliminary effectiveness of HRS-7058 in patients with KRAS G12C–mutated advanced pancreatic cancer after failure of 1–2 prior therapies. It is a single-arm trial where all participants receive HRS-7058, with outcomes assessed by standard imaging and safety monitoring. Eligible participants have measurable disease, good performance status, and adequate organ function, and must be able to take oral medication and adhere to follow-up visits. The study aims to determine whether inhibiting KRAS G12C with HRS-7058 can demonstrate clinical activity in this challenging population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Informed consent was obtained from all participants before participating in the study.
2. Age from 18 to 75 years old (including both ends), regardless of gender;
3. Patients with locally advanced unresectable, recurrent unresectable or metastatic pancreatic cancer, and adenocarcinoma confirmed by cytology or histological pathology;
4. Participants had received at least one previous systemic therapy
5. At least one measurable lesion according to RECIST v1.1;
6. ECOG PS score 0 or 1;
7. The expected survival time was more than 3 months.
8. They were able to swallow medications and were able to adhere to trial and follow-up procedures.
9. Adequate bone marrow and organ function within 7 days before the first dose (no use of blood components and/or cell growth factors within 14 days before starting study treatment;
10. Women of childbearing potential had to agree to abstain from sexual intercourse (heterosexual intercourse) or to use a highly effective method of contraception from the time they provided informed consent until 30 days after the last dose of the trial drug. A blood test for human chorionic gonadotropin (HCG) had to be negative within 7 days before starting study treatment and she had to be nonlactating (if a serum pregnancy test was positive, pregnancy was ruled out and enrollment was confirmed after discussion with the sponsor). Men whose partner was a woman of childbearing potential had to agree to abstain from sex or to use a highly effective method of contraception from the time they provided written informed consent until 30 days after the last dose of the trial drug. Male patients also had to agree not to donate sperm during the same period

Exclusion Criteria:

1. Presence of untreated or active central nervous system (CNS) metastases. Participants with a history of leptomeningeal metastasis or current leptomeningeal metastasis, brainstem metastasis, spinal cord metastasis, and/or spinal cord compression.
2. Subjects who had received general anesthesia
3. Subjects with a history of myocardial infarction or unstable angina pectoris
4. Subjects with atrioventricular block or cardiac insufficiency
5. Subjects with a history of ischemic stroke or transient ischemic attack
6. Subjects with poor blood pressure control after medication
7. Subjects with abnormal clotting function
8. Subjects with a history of mental illness and a history of cognitive impairment epilepsy
9. Subjects with a history or possibility of a difficult airway
10. Subject with a history of substance abuse and drug abuse
11. Adrenoceptor agonists or antagonists were used before randomization
12. Abnormal values in the laboratory
13. Thyroid dysfunction
14. Allergic to a drug ingredient or component
15. Pregnant or nursing women
16. No birth control during the specified period of time
17. Participated in clinical trials of other drugs (received experimental drugs)
18. The inestigators determined that other conditions were inappropriate for participation in this clinical trial

Where it's running

• Jiangsu Province Hospital
  Nanjing, Jiangsu, China Recruiting
• Tianjin Medical University Cancer Institute & Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Meng Qin
• Email: meng.qin.mq8@hengrui.com
• Phone: +0518-81220121

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.