KN510 and KN713 with mFOLFIRINOX for advanced pancreatic cancer

An Open-label, Dose-finding and Dose-expansion, Phase I/IIa Clinical Trial to Evaluate the Safety and Efficacy of KN510713 in Combination With mFOLFIRINOX in Patients With Locally Advanced or Metastatic Pancreatic Cancer

This trial will try to see if adding oral KN510 and KN713 to mFOLFIRINOX helps adults with unresectable locally advanced or metastatic pancreatic cancer.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 19 Years to 75 Years
• Sex: All
• Sponsor: New Cancer Cure-Bio Co.,Ltd. (Industry-sponsored)
• Drugs / interventions: chemotherapy, methotrexate, prednisone
• Locations: 1 site (Goyang-si)
• Trial ID: NCT07114861 on ClinicalTrials.gov

What this trial studies

This is a Phase 1/2, open-label study combining oral KN510 and KN713 with the mFOLFIRINOX chemotherapy regimen in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma. Part 1 uses dose-finding cohorts (including KN510 120 mg/day with KN713 at 90 mg/day or 120 mg/day) to identify a tolerable regimen, and Part 2 expands at the selected dose to further characterize safety and preliminary anti-tumor activity. Eligible participants are adults 19–75 years old with histologically or cytologically confirmed unresectable or metastatic disease, measurable lesions by RECIST 1.1, ECOG 0–1, and no prior systemic chemotherapy for advanced disease. Key outcomes include safety, tolerability, and measures of tumor response and clinical benefit.

Who should consider this trial

Good fit: Adults aged 19–75 with histologically or cytologically confirmed unresectable locally advanced or metastatic PDAC, measurable disease, ECOG performance status 0–1, and no prior systemic chemotherapy for advanced disease are ideal candidates.

Not a fit: Patients who have already received systemic chemotherapy for advanced or metastatic pancreatic cancer, who lack measurable disease, or who have poor performance status (ECOG >1) are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, the combination could increase tumor response rates and potentially extend survival compared with historical outcomes for mFOLFIRINOX alone.

How similar studies have performed: Combining novel oral targeted agents with aggressive chemotherapy like FOLFIRINOX is a relatively new approach in pancreatic cancer and has had limited, early-stage success to date, so this combination remains largely unproven.

Eligibility criteria

Inclusion Criteria:

1. Adult male and female subjects aged 19 to 75 years at the time of providing written informed consent
2. Subjects with histologically or cytologically confirmed unresectable, locally advanced or metastatic PDAC who are scheduled to receive treatement with mFOLFIRINOX
3. Subjects who have not received prior systemic chemotherapy for locally advanced or metastatic pancreatic cancer (Note: Prior neo-adjuvant or adjuvant systemic chemotherapy is allowed if there was no disease progression within 6 months after the last dose of chemotherapy)
4. Subjects with at least one measurable lesion according to RECIST ver1.1
5. Subjects with an ECOG performance status of 0 or 1
6. Subjects with an expected survival of at least 12 weeks
7. Subjects with adequate hematologic function, renal and hepatic function, and coagulation function based on the following laboratory criteria (only one repeat of laboratory tests is permitted during the screening period)
8. Subjects who have been informed about the clinical study and voluntarily signed the written informed consent form

Exclusion Criteria:

1\) Known hypersensitivity to the IP, combination anticancer agents, their components, or drugs of a similar class 2) Subjects with any of the following medical history, or surgical/procedural history identified:

1. History of any malignancy other than pancreatic cancer within 5 years prior to screening (Subjects with a history of basal cell carcinoma, squamous cell carcinoma of the skin, thyroid cancer, or carcinoma in situ at other sites may be eligible if the cancer was successfully treated and there has been no recurrence for more than 3 years, as determined by the investigator).
2. Major surgery requiring general anesthesia or ventilatory support within 4 weeks prior to baseline (Video-assisted thoracoscopic surgery (VATS) or ONC surgery is limited to 2 weeks).
3. Clinically significant arrhythmia, acute myocardial infarction, unstable angina, or NYHA class III or IV heart failure within 24 weeks prior to baseline.
4. Pulmonary thrombosis, deep vein thrombosis, or other serious, life-threatening pulmonary diseases (e.g., acute respiratory distress syndrome, lung failure), or conditions such as asthma or COPD considered inappropriate for study participation, occurring within 24 weeks prior to baseline.
5. Known DPD deficiency
6. Subjects known to carry the genetic polymorphism of UGT1A1\*6 or UGT1A1\*28 as homozygotes (UGT1A1\*6/\*6 or UGT1A1\*28/\*28) or as compound heterozygotes (UGT1A1\*6/\*28)
7. Known fructose intolerance 3) Comorbidities or conditions as follows:

(1) Peripheral neuropathy of moderate (Grade 2) or higher (2) Chronic diarrhea or inflammatory bowel disease (Crohn's disease, ulcerative colitis) (3) Ileus or Intestinal obstruction (4) Clinically significant symptoms of ILD or pulmonary fibrosis requiring steroid therapy (5) Chronic kidney disease requiring dialysis (6) Clinically significant symptomatic or uncontrolled central nervous system or brain metastases (permitted if systemic corticosteroids were discontinued ≥4 weeks prior to baseline and the metastases have remained stable for ≥4 weeks) (7) Uncontrolled hypertension (SBP/DBP ≥160/100 mmHg) (8) QTc \>450 ms on ECG (9) Active hepatitis B or hepatitis C (10) Known HIV infection (11) Conditions interfering with oral intake (e.g., dysphagia) or absorption (e.g., celiac disease, Crohn's disease, or a clinically significant bowel resection that may affect drug absorption) (12) Subjects with a history or suspected symptoms of gastro-esophageal reflux disease (GERD), including gastric ulcer, duodenal ulcer, or reflux esophagitis (13) Parkinson's disease, parkinsonism, tremor, restless leg syndrome, or other related movement disorders (14) Clinically significant symptomatic or uncontrolled ascites or pleural effusion (15) Subjects who, in the investigator's judgment, have a disease or condition sufficiently serious to influence the study results, or for whom the concomitant anticancer agents are contraindicated 4) Prior medications or treatments as follows:

1. Radiotherapy within 2 weeks prior to screening (radiotherapy for symptom relief or bone lesions at high risk of pathological fracture is allowed if completed ≥1 week before the planned enrollment, provided that the treated lesions is not selected as target lesions for RECIST evaluation)
2. Use of PPIs other than the IP within 2 weeks prior to screening
3. Administration of any antithrombotic agents, including antiplatelet or anticoagulant drugs, within 2 weeks prior to screening, or an anticipated need for such medication during the study period (the use of low-molecular-weight heparin \[LMWH\] for prophylaxis or management of venous thrombosis is permitted during the study)
4. Use of rilpivirine-containing products within 2 weeks prior to screening
5. Use of atazanavir-containing products within 2 weeks prior to screening
6. Current administration of, or anticipated need for strong CYP3A4 inhibitors or inducers
7. Current administration of, or anticipated need for CYP2C19 substrates, strong inhibitors, or inducers
8. High dose methotrexate (≥1000 mg/m2)
9. St. John's wort
10. Requirement for continuous use (≥4 weeks) of systemic corticosteroids equivalent to \>10 mg/day prednisone (local administration such as intra-articular, intranasal, ophthalmic, or inhaled corticosteroids, and short-term use for the treatment or prophylaxis of contrast-media allergy or AEs \[e.g., vomiting\] are permitted)
11. Current administration of, or anticipated need for sorivudine 5) Pregnant or breastfeeding women, or women of childbearing potential and men who are unwilling to remain abstinent or use appropriate contraception until 12 months (for men) or 15 months (for women) after the last administration of IP/concomitant medication following study enrollment 6) Participation in another clinical trial and administration or application of an investigational drug or device within 4 weeks prior to screening 7) Any other subject who, in the investigator's judgment, is unsuitable for participation in this study

Where this trial is running

Goyang-si

• National Cancer Center — Goyang-si, South Korea (Recruiting)

Study contacts

• Study coordinator: Joon Hee Kang, Ph.D

Conditions Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma