KN060 to prevent clotting during hemodialysis for people with end-stage kidney disease

Phase 1b Clinical Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of KN060 in Patients With End Stage Renal Disease Receiving Regular Hemodialysis

This trial will test KN060 in adults with end-stage renal disease on regular hemodialysis to see if it is safe and can reduce clotting in the dialyzer, extracorporeal circuit, and arteriovenous fistulas.

Quick facts

• Phase: PHASE1; PHASE2
• Study type: Interventional
• Enrollment: 12 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Suzhou Alphamab Co., Ltd. (industry)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT07201467 on ClinicalTrials.gov

What this trial studies

This Phase 1/2 interventional trial enrolls adults with stable end-stage renal disease who receive regular thrice-weekly hemodialysis through a functioning AVF/AVG. Participants receive multiple doses of KN060 with close monitoring for safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD). The study also measures immunogenicity and tracks clotting events in the dialyzer, extracorporeal circuit, and arteriovenous fistulas to explore potential efficacy. Safety and PK/PD data will guide dose selection and inform whether KN060 reduces dialysis-related thrombosis.

Who should consider this trial

Good fit: Adults aged 18–80 with end-stage renal disease receiving stable thrice-weekly hemodialysis via a functional AVF or AVG, with Kt/V ≥ 1.2 and BMI between 18 and 28 kg/m², are the intended participants.

Not a fit: Patients not receiving regular hemodialysis (for example peritoneal dialysis), those with unstable clinical status, infected or nonfunctional vascular access, outside the BMI or age ranges, or unable to attend the Beijing site are unlikely to benefit from participation.

Why it matters

Potential benefit: If successful, KN060 could offer a safer or more effective way to prevent clotting in the dialysis circuit and protect vascular access for patients on hemodialysis.

How similar studies have performed: Standard anticoagulation methods (e.g., heparin, citrate) are established for preventing dialysis clotting, but KN060 represents a novel investigational agent with limited prior data in the ESRD dialysis population.

Eligibility criteria

Inclusion Criteria:

1. Male or female subjects aged between 18 and 80 years (inclusive);
2. 1 8 kg /m \^2 \<BMI \<2 8 kg /m\^2 ;
3. Diagnosis of ESRD and be receiving regular, stable hemodialysis treatment within the three months prior to screening: dialysis is performed through a functional, non-infected graft arteriovenous fistula / autologous arteriovenous fistula ( AVG/AVF ) ; dialysis is performed three times per week, with at least 3.5 hours per session ( at least 75% of dialysis sessions within the four weeks prior to randomization meet the this criteria) ;
4. The clinical status of the underlying ESRD is stable (assessed by the investigator) ;
5. Kt/V ≥ 1.2 within 3 months before screening ;
6. Male subjects: From the time they sign the informed consent form until 3 months after the last dose of KN060 , they agree to take effective contraceptive measures and avoid sperm donation ( effective contraceptive methods include: consistent scientific use of condoms , vasectomy , or partners who have undergone tubal ligation or hysterectomy, or have an intrauterine device implanted, etc. );
7. Women who are infertile and have no plans to have children (surgical infertility: such as after hysterectomy, bilateral salpingectomy , bilateral oophorectomy; or natural menopause: amenorrhea for ≥ 12 months and serum follicle-stimulating hormone (FSH) at menopausal levels ).

Exclusion Criteria:

1. A history of malignant tumor;
2. History of mechanical/artificial heart valve replacement surgery;
3. History of major medical events within 3 months before screening , such as acute coronary syndrome, stroke , major organ bleeding, acute heart failure, systemic thromboembolic events , major surgery, etc. , or history of AVF/AVG functional loss;
4. Using anticoagulant/antiplatelet drugs due to disease treatment , such as warfarin , dabigatran, rivaroxaban , clopidogrel , or aspirin \>100 mg/day (investigators are allowed to use heparin / low molecular weight heparin during dialysis, depending on the situation );
5. There is a high risk of bleeding, or abnormal bleeding-related indicators:

1） Bleeding requiring hospitalization or clinically significant active bleeding within 3 months before screening ; prolonged arteriovenous fistula compression time within the past month; 2） Platelet count (PLT) \<100 × 10\^ 9 /L ( PLT between 75-100 × 10\^9 /L , determined by the investigator after comprehensive evaluation), hemoglobin ( Hb ) \< 90 g/L ; 3） Normalized ratio INR\>1.4 , activated partial thromboplastin time ( APTT ) \> 1.2 times ULN ; 4） Liver disease-related laboratory abnormalities: increased bleeding risk due to coagulation disorders , alanine aminotransferase (ALT) \> 3 times ULN , aspartate aminotransferase ( AST) \> 3 times ULN , total bilirubin (TB) \> 2 times ULN and direct bilirubin proportion \> 20%; 5） Poor blood pressure control in the past month before screening (judged by the investigator, such as repeated diastolic blood pressure ≥100 mmHg and/or systolic blood pressure ≥180 mmHg ) ; 6） Underwent brain, spinal or eye surgery (excluding cataract surgery) within three months before screening; 7） The patient has a bleeding disorder, a medical history that may increase the risk of bleeding, any condition that the investigator believes increases the risk of bleeding, or a history of severe bleeding disorders, such as massive gastrointestinal bleeding or cerebral hemorrhage ; 6. Supine blood pressure is \< 90/50 mmHg , or \> 170/100 mmHg (one retest is allowed) during screening; 7. Electrocardiogram during screening: heart rate \< 45 beats / min or \> 110 beats / min, QTcF \> 500 ms, any significant arrhythmia or conduction abnormality ( e.g. Second degree or above atrioventricular block, preexcitation syndrome (except those who have undergone radical radiofrequency ablation) , non-sustained or sustained ventricular tachycardia (one retest is allowed); 8. History (\<1 year) of drug or alcohol abuse or dependence before screening; 9. Have a history of allergy, or be allergic to the experimental drug/similar drugs or excipients; 10. Human immunodeficiency virus (HIV ) infection, syphilis infection, active HBV infection (HBV -DNA\>ULN ), active HCV infection (HCV - RNA \> ULN ) ; 11. Participated in another clinical trial and received trial drugs within 3 months before screening (signing ICF); 12. Plan to receive a kidney transplant during the trial or within 3 months after completing this trial; 13. Xanthine, coffee (small amounts of caffeine from normal food sources, such as chocolate, are permitted), or alcohol cannot be prohibited during the study; 14. Any concomitant disease or condition that the investigator believes may interfere with the study drug, affect study data, or pose a risk to patient safety.

Where this trial is running

Beijing, Beijing Municipality

• Peking University People's Hospital — Beijing, Beijing Municipality, China (RECRUITING)

Study contacts

• Principal investigator: Li Zuo, Doctor — Peking University People's Hospital
• Study coordinator: Yanrong Dong, Master

Conditions: End-Stage Renal Disease Requiring Haemodialysis