Joshi's step with buccal graft repair for nearly obliterated bulbar urethral strictures
Official title: Joshi's Step With Buccal Mucosal Graft Urethroplasty in Nearly Obliterated Bulbar Urethral Stricture: A Prospective Study
Run by Tanta University · NCT07088198 · Data updated 2026-11-12
This will try Joshi's step combined with a buccal mucosal graft to improve urine flow and surgical outcomes for people with nearly obliterated bulbar urethral strictures.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Men only |
| Enrollment | 50 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Status | Recruiting |
| Started | May 1, 2024 |
| Main results expected | November 1, 2025 |
| Study ends | November 1, 2025 |
| Registry record updated | July 28, 2025 |
| Trial ID | NCT07088198 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with primary, non‑traumatic nearly obliterated bulbar urethral strictures where the narrowest portion is less than 1.5 cm and who have not had prior urethroplasty are ideal candidates.
✕Probably not a fit
Patients with traumatic, redo, fully obliterated, or long-segment bulbar strictures are excluded and are unlikely to benefit from this specific technique.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center interventional program applies a non-resecting modification (Joshi's step) to augmented buccal mucosal graft urethroplasty for very narrow bulbar strictures. The technique marks the narrowest segment without excising the native urethral plate and reapproximates mucosal edges before graft augmentation. Eligible patients are those with primary, non‑traumatic, nearly obliterated bulbar strictures under 1.5 cm in length, and outcomes will focus on functional urinary results and surgical success. Patients with traumatic, redo, fully obliterated, or long segment strictures are excluded.
Why it matters
Potential benefit: If successful, the approach could improve urine flow and surgical success while preserving more of the native urethra compared with resectional repairs.
How similar studies have gone: This non-resecting modification (Joshi's step) was described in 2022 and remains a relatively new technique with limited published outcome data to date.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with primary bulbar urethral stricture. * Patients with non-traumatic bulbar urethral stricture. * Patients with nearly obliterated bulbar urethral stricture, with the narrowest portion of the stricture is less than 1.5 cm in length. Exclusion Criteria: * Patients with traumatic bulbar urethral stricture. * Patients with redo bulbar urethral stricture. * Patients with obliterated bulbar urethral stricture. * Patients with nearly obliterated long bulbar urethral stricture.
Where it's running
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Tanta University
Tanta, El-Gharbia, Egypt Recruiting
Study contacts
- Study coordinator: Mohamed I Elmaadawy, MD
- Email: Mohamed.elmaadawy@med.tanta.edu.eg
- Phone: 00201060245430
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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General versus spinal anesthesia with local numbing for buccal mucosal graft urethroplasty
This project will see if spinal anesthesia plus local numbing causes less mouth and overall postoperative pain than general anesthesia for adult men having urethroplasty with a buccal (cheek) graft.
-
Comparing cheek (buccal) tissue versus penile skin grafts for repairing long anterior urethral strictures
This will test whether cheek (buccal) tissue or penile skin works better to repair long anterior urethral strictures in men who need urethroplasty.
-
Oral mucosa versus labial grafts for female urethral reconstruction
This trial will see if oral mucosal grafts or labial grafts work better for women having urethroplasty to treat urethral stricture.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.