Isometric resistance exercise to lower blood pressure in patients with hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of isometric resistance exercises (IREs) in controlling blood pressure among patients with hypertension who do not meet physical activity guidelines. A total of 390 participants will be randomly assigned to either an IRE group, performing wall squats, or a control group engaging in passive stretching exercises. The intervention will last for 24 weeks, with adherence monitored through smartwatches. The study aims to determine if IREs can effectively reduce blood pressure as measured by ambulatory blood pressure monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* a suboptimal daytime SBP of \>135-160 mmHg on a 24-h ABPM
* reported no regular physical activity or less than that recommended for adults by the World Health Organization (e.g. \<150 minutes of moderate-intensity aerobic exercise per week)
* on stable doses of anti-HT medication(s) for ≥4 weeks if the patient is receiving drug treatments;
* agree for no drug changes during the intervention period (24 weeks);

Exclusion Criteria:

* cannot provide informed consent
* unwillingness to repeat ABPM
* relative contraindications to ABPM (i.e. diagnosed atrial fibrillation, nighttime workers, occupational drivers, or patients with bleeding tendencies)
* severe osteoarthritis pending knee replacement surgery
* known secondary HT
* use of ≥3 anti-HT medications at maximum doses or ≥4 anti-HT medications
* SBP or DBP are \>160 mmHg or \>100 mmHg, respectively, on ABPM at baseline or at 12 weeks follow-up to ensure safety
* pregnancy/breastfeeding
* active malignancy

Where it's running

• Lek Yuen General Outpatient Clinic
  Hong Kong, Hong Kong Recruiting
• School of public health and primary care
  Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Eric Kam-Pui Lee, MSc, FRACGP
• Email: lkp032@cuhk.edu.hk
• Phone: 22528462

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.