Is preoperative urine culture before TURB necessary for preventing fever UTIs?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a non-inferiority randomized trial evaluating whether omitting routine preoperative urine culture (UC) before transurethral resection of the bladder (TURB) is not worse than performing the culture in preventing postoperative febrile UTIs. Participants are adults scheduled for TURB to treat or diagnose bladder tumors and are randomized to either receive a preoperative UC or not. All participants are followed for 30 days after surgery to track incidence and severity of febrile UTIs, with safety and antibiotic-use patterns monitored. The study context notes that current guidelines recommend UC screening, but high-quality evidence showing benefit is lacking. The trial is conducted at multiple French centers with Poitiers University Hospital as the lead sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient aged 18 or over
* Scheduled for TURB surgery for a suspected or confirmed diagnosis of bladder tumor
* Affiliated person or beneficiary of a social security scheme
* Written informed consent obtained from the participant

Exclusion Criteria:

* Patient with active UTI
* Planned combined surgery
* Patient previously included in this research protocol
* People benefiting from enhanced protection, namely minors, people deprived of their liberty by judicial or administrative decision, people staying in a health or social institution, adults under legal protection
* Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation : oral, intravaginal, transdermal; Progestogen-only hormonal contraception associated with inhibition of ovulation : oral, injectable, implantable; Intrauterine device; Intrauterine hormone-releasing system; Bilateral tubal occlusion) or permanent sterilization methods ( hysterectomy, bilateral salpingectomy, bilateral oophorectomy).

Where it's running

• Hospices Civils de Lyon
  Lyon, France Recruiting
• Centre Hospitalier Intercommunal de Mont de Marsan et du Pays des Sources
  Mont-de-Marsan, France Recruiting
• CHU Poitiers - Service de chirurgie urologique
  Poitiers, France Recruiting
• Centre Hospitalier Universitaire d'Angers
  Angers, France Not yet recruiting
• Centre Hospitalier Universitaire de Grenoble Alpes
  Grenoble, France Not yet recruiting
• Centre Hospitalier de Chartres - Hôpital Louis Pasteur
  Le Coudray, France Not yet recruiting

Study contacts

• Study coordinator: Maxime VALLEE, MD
• Email: maxime.vallee@chu-poitiers.fr
• Phone: +33 5 16 60 42 22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.