Investigation of blood mutations in elderly lymphoma patients
Official title: Chemotherapy-induced Genomic Damage in Elderly Patients With Lymphoma: Prevalence, Evolution, and Clinical Consequences
Run by Copenhagen University Hospital, Rigshospitalet · NCT05245487 · Data updated 2026-11-12
This study is testing how blood mutations affect older patients with B-cell Non-Hodgkin lymphoma during chemotherapy to see who might do better with standard treatments or newer options that have fewer side effects.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | January 1, 2022 |
| Main results expected | December 31, 2025 |
| Study ends | January 1, 2035 |
| Registry record updated | December 22, 2023 |
| Trial ID | NCT05245487 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are elderly patients aged 60 and older with a diagnosis of B-cell Non-Hodgkin lymphoma requiring second-line or higher systemic treatment.
✕Probably not a fit
Patients who are unable to provide written consent or are non-Danish citizens will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate blood mutations in elderly patients diagnosed with B-cell Non-Hodgkin lymphoma who require systemic treatment. It focuses on patients aged 60 and older, examining the impact of chemotherapy on blood cell mutations and the associated risks of treatment side effects and mortality. Blood samples will be collected at various stages of treatment, and quality of life questionnaires will be administered electronically. The study seeks to identify which patients may benefit from traditional chemotherapy versus novel therapies with fewer side effects.
Why it matters
Potential benefit: If successful, this study could help tailor lymphoma treatments to minimize toxicity and improve outcomes for elderly patients.
How similar studies have gone: While studies have examined blood mutations in younger patients, this investigation into elderly populations is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of r/r B-cell Non-Hodgkin lymphoma * In need of systemic treatment with second (2.) or higher line of active therapy for lymphoma * 60 years of age or older (no age maximum) Exclusion Criteria: * Unable to give written consent * Non-Danish citizens
Where it's running
-
Dept. of Hematology, Rigshospitalet
Copenhagen, Denmark Recruiting
Study contacts
- Principal investigator: Simon Husby, MD PhD — Copenhagen University Hospital, Rigshospitalet
- Study coordinator: Simon Husby, MD PhD
- Email: simon.husby.01@regionh.dkZZZZZZ
- Phone: +45 3545 6060
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.