Clinical trial Recruiting at 1 site Observational Ages 60 and up

Investigation of blood mutations in elderly lymphoma patients

Official title: Chemotherapy-induced Genomic Damage in Elderly Patients With Lymphoma: Prevalence, Evolution, and Clinical Consequences

Run by Copenhagen University Hospital, Rigshospitalet · NCT05245487 · Data updated 2026-11-12

This study is testing how blood mutations affect older patients with B-cell Non-Hodgkin lymphoma during chemotherapy to see who might do better with standard treatments or newer options that have fewer side effects.

More Lymphoma trials

Quick facts

Study typeObservational
Ages60 Years and up
SexAll
Enrollment300 (estimated)
SponsorCopenhagen University Hospital, Rigshospitalet
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Copenhagen)
StatusRecruiting
StartedJanuary 1, 2022
Main results expectedDecember 31, 2025
Study endsJanuary 1, 2035
Registry record updatedDecember 22, 2023
Trial IDNCT05245487 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are elderly patients aged 60 and older with a diagnosis of B-cell Non-Hodgkin lymphoma requiring second-line or higher systemic treatment.

Probably not a fit

Patients who are unable to provide written consent or are non-Danish citizens will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate blood mutations in elderly patients diagnosed with B-cell Non-Hodgkin lymphoma who require systemic treatment. It focuses on patients aged 60 and older, examining the impact of chemotherapy on blood cell mutations and the associated risks of treatment side effects and mortality. Blood samples will be collected at various stages of treatment, and quality of life questionnaires will be administered electronically. The study seeks to identify which patients may benefit from traditional chemotherapy versus novel therapies with fewer side effects.

Why it matters

Potential benefit: If successful, this study could help tailor lymphoma treatments to minimize toxicity and improve outcomes for elderly patients.

How similar studies have gone: While studies have examined blood mutations in younger patients, this investigation into elderly populations is novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of r/r B-cell Non-Hodgkin lymphoma
* In need of systemic treatment with second (2.) or higher line of active therapy for lymphoma
* 60 years of age or older (no age maximum)

Exclusion Criteria:

* Unable to give written consent
* Non-Danish citizens

Where it's running

  • Dept. of Hematology, Rigshospitalet
    Copenhagen, Denmark
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.