Investigation of blood clot environment in stroke patients
Multimodal Investigation of Intracranial Clot Environment
University Hospital, Montpellier · NCT04421326
This study looks at blood samples from stroke patients to see how immune cells and certain proteins around blood clots might affect brain damage and help find new treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | University Hospital, Montpellier (other) |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT04421326 on ClinicalTrials.gov |
What this trial studies
This observational study analyzes blood collected from around the clot during the acute phase of ischemic stroke to understand the physiological mechanisms that contribute to cerebrovascular damage. It focuses on the accumulation of immune cells and the regulation of specific chemokines and cytokines that may affect the integrity of blood vessels in the brain. By examining these factors, the study aims to provide insights into the pathophysiology of stroke and potential therapeutic targets.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a large arterial trunk occlusion confirmed by imaging and who were independent in daily activities prior to the stroke.
Not a fit: Patients who are unable to undergo endovascular treatment or those under guardianship may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for acute ischemic stroke.
How similar studies have performed: While similar studies have explored aspects of stroke and immune response, this specific multimodal investigation of the clot environment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Over 18 years of age, 2. Non-dependent for activities of daily living prior to the onset of the MI (Modified Rankin Score \>2) 3. Having an occlusion of a large arterial trunk proven by imaging (angio-MRI or angio-scanner). Exclusion criteria: 1. Patients initially admitted but for whom endovascular treatment will not finally be performed (re-infusion, catheterization failure...) will be excluded from the study. 2. Major patients under guardianship or curatorship or patients deprived of liberty
Where this trial is running
Montpellier
- University Hospital of Montpellier — Montpellier, France (RECRUITING)
Study contacts
- Principal investigator: Vincent COSTALAT, MD PhD — Montpellier University Hospital
- Study coordinator: Cyril DARGAZANLI, MD MSc
- Email: c-dargazanli@chu-montpellier.fr
- Phone: 467337532
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Ichemic Stroke, Brain Ischemia, Stroke, Blood Brain Barrier, Ischemia, Thrombus, Interventional Neuroradiology