Investigating Vitamin D Deficiency and Genetic Factors in Pregnant Women with Hypertension
Association of Vitamin D Deficiency With Selected Vitamin D Receptor (VDR) Gene Polymorphism in Gestational Hypertension Among Malaysian Women: A Prospective Genetic Biomarker for Early Intervention Strategy
This study is trying to see how common Vitamin D deficiency is in pregnant women with high blood pressure in Malaysia and if certain genes play a role in this issue.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 19 Years to 50 Years |
| Sex | Female |
| Sponsor | Universiti Putra Malaysia Academic / other |
| Locations | 1 site (Serdang, Selangor Darul Ehsan) |
| Trial ID | NCT05659173 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the prevalence of Vitamin D deficiency among pregnant women in Malaysia and explore its associated risk factors, particularly focusing on those with gestational hypertension. The study will involve 363 Malay pregnant women, collecting socio-demographic, clinical, and anthropometric data through structured interviews. Additionally, blood samples will be taken to analyze genetic variations in the vitamin D receptor (VDR) that may contribute to hypertensive disorders during pregnancy. This research seeks to provide insights into the genetic factors influencing Vitamin D deficiency and its potential impact on maternal health.
Who should consider this trial
Good fit: Ideal candidates for this study are Malay pregnant women between 20 to 42 weeks of gestation, with or without pregnancy-induced hypertension.
Not a fit: Patients who are not of Malay ethnicity or those with chronic diseases affecting Vitamin D metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and early supplementation strategies for Vitamin D in pregnant women, potentially reducing the incidence of gestational hypertension.
How similar studies have performed: While studies have shown associations between Vitamin D deficiency and pregnancy complications in various populations, this specific investigation into VDR genetic variations among Malaysian women is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Malay pregnant women with gestational age between 20 weeks till 42 weeks. (The gestational age will be determined from the first day of the last menstrual cycle or measurement of fetal crown rump length) 2. Malay pregnant women with viable pregnancy with or without pregnancy induced hypertension or its complications (pre-eclampsia, eclampsia, HELLP syndrome etc). 3. Literate in either English or Malay languages. 4. Agreement to follow-up till delivery and provision of written informed consent. Exclusion Criteria: 1. Non-viable pregnancy at the time of recruitment. 2. Women already on vitamin D supplements or any other drugs that can interfere with vitamin D absorption or metabolism at the time of recruitment. 3. Women with chronic hypertension diagnosed prior to pregnancy. 4. Pregnant women with any other chronic disease that is known to affect vitamin D such as, autoimmune disease and any malignancy
Where this trial is running
Serdang, Selangor Darul Ehsan
- Hospital Pengajar UPM — Serdang, Selangor Darul Ehsan, Malaysia (Recruiting)
Study contacts
- Principal investigator: Nurul I Basri, MbChb — Universiti Putra Malaysia
- Study coordinator: Nurul I Basri
- Email: nurul.iftida@upm.edu.my
- Phone: 0397699339
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.