Investigating vancomycin levels in patients on CRRT with oXiris membrane

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how vancomycin behaves in patients undergoing continuous renal replacement therapy (CRRT) using the oXiris membrane, which is known to absorb inflammatory cytokines. It aims to measure the pharmacokinetics of vancomycin by drawing blood samples at various time points after drug administration. The study hypothesizes that the oXiris membrane may reduce vancomycin levels, similar to findings with other membranes. The results will help clarify the drug's behavior in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged more than 18 years.
* Admitted to the intensive care unit of Ramathibodi Hospital.
* Under continuous renal replacement therapy (CRRT) with CVVHDF using oXiris filter.
* Received vancomycin at least once after starting CRRT with CVVHDF using oXiris filter.
* who have signed the informed consent document.

Exclusion Criteria:

* Patients with a history of vancomycin allergy.
* Patients expected to die within 24 hours after inclusion in study.
* Patients with circuit clotting occurring more than 2 hours during the blood draw period.
* Patients treated with extracorporeal membrane oxygenation (ECMO).
* Patients with a history of kidney transplantation.
* Pregnant or breastfeeding women.
* Patients who have decided to receive palliative care.
* Patients on hemodialysis or peritoneal dialysis.

Where it's running

• Facullty of Pharmacy Mahidol University
  Bangkok, Payathi, Thailand Recruiting

Study contacts

• Study coordinator: chidtawan Hirunsomboon, PharmD
• Email: chidtawan.hir@mahidol.ac.th
• Phone: +66-988309558

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.